Zinc fingers of Zif

Figure 10.3 Schematic diagram of the stmcture of three zinc fingers of Zif 268 bound to DNA. The three zinc fingers, which bind In tandem to the major groove of DNA, are colored blue, red and green from the N-terminus. The zinc fingers have the same stmcture and bind in a similar way with the N-terminus of the a helix pointing into the major groove. (Adapted from N.P. Pavletich et al.. Science 261 1701-1707, 1993.)...

Figure 10.4 Detailed view of the binding of the second zinc finger of Zif 268 to DNA. Two side chains, Arg 46 and His 49, form sequence-specific interactions with DNA. There are also three nonspecific interactions between phosphate groups of the DNA and the side chains of Arg 42, Ser 45, and His 53.

Table 17.2 Amino acid sequences of the second zinc finger of Zif 268 and the designed peptide FSD-1...

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