Toxin natural

Clavicepspurpurea. Indeed, these natural toxins have given many useful leads in the design of new pesticides, biocides, or drugs. 

Keeler, R.F. and Tu, A.T. (Eds.) (1983). Handbook of Natural Toxins Vol 1 Plant and Eungal Toxins. New York Marcel Dekker. 

Some Formal Considerations. As with most natural toxins, detection methods for the saxitoxins are an essential prerequisite for most studies of them, as well as for monitoring programs to ensure the safety of food products that may contain them. Furthermore, the degree of success of such efforts is dependant on the characteristics of the detection method used. Detection of the saxitoxins is particularly challenging because of the large number of different but related compounds that must be dealt with, the low levels that must be detected, and their chemical characteristics. Given these factors it is useful to dwell briefly on some underlying principles. 

Natural Toxins from Cyanobacteria (Blue-Green Algae)... 

At this time, a solid phase automatic peptide synthesizer was acquired, so we attempted total synthesis of Sh I. A solid phase synthesis of Ax I (antho-pleurin A) had previously been reported in an abstract (36). The synthetic Ax I possessed only 11% of the toxicity of the natural toxin. 

First, we investigated whether Sh I could be reduced under denaturing conditions, exposed to the hydrogen fluoride cleavage procedure we intended to use, then reoxidized and refolded successfully. The toxicity of the resulting polypeptide (50% yield) was the same as that of the untreated natural toxin. 

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