Lymphoid leukemia

HiBASAMi H, ACHiwA Y, FUJIKAWA T and KOMIYA T (1996) Induction of programmed cell death (apoptosis) in human lymphoid leukemia cells by catechin compounds . Anticancer Res, 16, 1943-46. 

A similar phenomenon has also been reported in B cells derived from chronic lymphoid leukemia (CLL) patients in which mFas is deficient or defective. Fresh de novo CLL cells, which express low levels of mFas, are resistant to agonistic anti-Fas mAb-mediated apoptosis, while CLL cells that acquire abundant mFas after short-term culture become sensitive (T4) to such induction of apoptosis. This flexibility in production of the isoforms is expected to provide a target for selective molecular therapy of tumors on the basis of manipulating decoy action of sFas. 

Apoptosis induction. The exposure of human lymphoid leukemia Molt 4B cells to sesamolin, a component of sesame seed, produced growth inhibition and the induction of apoptosis " ". 

Miyahara, Y., H. Hibasami, H. Kat-suzaki, K. Imai, and T. Komiya. Sesamolin from sesame seed inhibits proliferation by inducing apoptosis in human lymphoid leukemia Molt 4B cells. IntJMolMed 2001 7(4) 369-371. 

Ottmann OG, Druker BJ, Sawyers CL et al. A phase 2 study of imatinib in patients with relapsed or refractory Philadelphia ehromosome-positive aeute lymphoid leukemias. B/ood 2002 100 1965-1971. 

Acute lymphoid leukemia During the initial phase, vincristine and prednisone are used. Methotrexate and mercaptopurine are used for maintenance therapy. In addition, methotrexate is given intrathecally, with or without radiotherapy, to prevent meningeal leukemia. 

Mercaptopurine is used in the treatment of acute lymphoid leukemia. Maintenance therapy makes use of both methotrexate and 6-mercaptopurine. Mercaptopurine is absorbed well from the gastrointestinal tract. It is metabolized through (1) methylation of the sulfhydryl group and subsequent oxidation, and (2) conversion to 6-thiouric acid with the aid of xanthine oxidase, which is inhibited by allopurinol. Mercaptopurine may cause hyperuricemia. Its chief toxicities are hepatic damage and bone marrow depression. 

Acute lymphoid leukemia In the induction phase, vincristine is used with prednisone. 

In mice, effective in combination with cyclophosphamide against thalicarpine-resistant lymphoid leukemia LI210 646... 

F15. Foucar, K., Chronic lymphoid leukemias and lymphoproliferative disorders. Mod. Pathol. 12, 141-150(1999). 

The nucleosides 236 were evaluated for cytotoxicity on mouse lymphoid leukemia cells (84JMC1358). Compounds 242 were screened for their anticancer or anti-AIDS activities (91JHC1417). Anticarcinogen activity against sarcoma 180 ascite tumor cells in mice was shown by 90 [84JAP(K) 5962593]. 

Many l,2,4-triazolo-l,2,4-triazines showed biological activities such as antibacterial (74MIP1), antiviral (74MIP1), antimetabolic (74MIP1), antitumour (86JMC2231), and anti-inflammatory (83MIP1) activities as well as inhibition of lymphoid leukemia (71RRC311). 

All 90 hemoblastotic patients, including 30 cases of myeloid leukemia, 30 of lymphoid leukemia, 2 of hemocytoblastotic and 1 of histiocytic leukemia, 21 of Hodgkin s disease, 3 of multiple myeloma, and 1 of lympho-sarcomatosis, were followed chromatographically for several days and the increased excretion of the two kynurenines was confirmed. Fever is not a determining factor since the remission of fever did not have a normalizing effect on the metabolite excretion. The investigation was completed with the isolation of kynurenine and 3-hydroxykynurenine in pure form. 

Cheson BD, Vena DA, Barrett J, Freidlin B. Second malignancies as a consequence of nucleoside analogue therapy for chronic lymphoid leukemias. J Clin Oncol 1999 17(8) 2454-60. 

Murphy JL. Renal tubular acidosis In children treated with trimethoprim-sulfamethoxazole during therapy for acute lymphoid leukemia. Pediatrics. 1992 Jun 89(6 Pt 1) 1072-4. 

CD33 was first identified as a 67 kD differentiation marker for subsets of myeloid cells. It has also been useful as a marker for myeloid versus lymphoid leukemias. CD33 expression in cells of hematopoietic origin has led to the proposal that it participates in myeloid cell differentiation and mediates cellular interactions [240]. 

Tylocrebrine shows high activity against lymphoid leukemia LI210 in mice, the best results being obtained at a dose level of 10 mg/kg. (23). 

Knowles and Milner, 2000). Furthermore, these compounds are thought to be involved in the inhibition of certain cytochrome P-450 enzyme-dependent bioactivations of procarcinogens and protoxicants (Brady et al., 1991), as well as to increase levels of glutathione-S-transferase (GST), an enzyme of particular importance in the detoxification of xenobiotics in the body (Wilce and Parker, 1994). Most recently, the ability of various plants and plant extracts to influence apoptosis, or programmed cell death, in cancerous cells in an attempt to arrest their proliferation, has been the topic of much research. Allicin has been shown to induce apoptosis in a variety of cell lines, including human hepatocellular carcinoma cells (KIM-1) and human lymphoid leukemia (MOLT-4B) cells (Thatte et al., 2000). 

Davey MP, Bongiovanni KF, Kaulfersch W, Querter-mous T, Seidman JG, Herschfield MS, et al. Immunoglobuhn and T-ceE receptor gene rearrangement and expression in human lymphoid leukemia cells at different stages of maturation. Proc Natl Acad SciUS A 1986 83 8759-63. 

Torelli G, Grosveld G. Chronic myeloid leukemia may be associated with several bcr-abl transcripts including the acute lymphoid leukemia-type 7 kb transcript. Blood 1990 75 1146-53. 

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