Human ovarian cancer

Straubinger, R. M., Lopez, N. G., Debs, R. J., Hong, K., and Papahadjopoulos, D. (1988). Liposome-based therapy of human ovarian cancer Parameters determining potency of negatively charged and antibody-targeted liposomes, Cancer Res.. 48, 5237-5245. 

Scotton CJ, Wilson JL, Scott K, et al. Multiple actions of the chemokine CXCL12 on epithelial tumor cells in human ovarian cancer. Cancer Res 2002 62 5930-5938. 

Kryczek I, Lange A, Mottram P, et al. CXCL12 and vascular endothelial growth factor synergistically induce neoangiogenesis in human ovarian cancer. Cancer Res 2005 65 465 172. 

SH-SY5Y neuroblastoma, cisplatin-sensitive A2780 and cispla-tin-resistant A2780cis human ovarian cancer cells was observed, but upon irradiation 7 strongly reduced the viability of the cancer cells (Fig. 8). In the A2780 cell line, the complex was 80x more toxic than cisplatin under identical conditions, and ca. 15 x more effective against the cisplatin-resistant A2780cis cell line (33). The trans diazido-Pt(IV) complex therefore has remarkable cytotoxic properties. 

Fig. 4.9 Comparison of PDT-induced killing in human ovarian cancer cells by BF4 or Photofrin both incubated for 24 h at 2(uM concentration and illuminated with red (630 nm) or white light...

Kikuchi, Y., Sasa, H., Kita, T., Hirata, J., Tode, T., and Nagata, I. (1991). Inhibition of human ovarian cancer cell proliferation in vitro by ginsenoside Rh2 and adjuvant effects of cisplatin in vivo. Anticancer Drugs 2, 6S-67. 

It was carried out according to Schwikkard et al. [9] and Actinomycin D was used as a positive control [ 16]. Cytotoxicity was determined against A2780 human ovarian cancer cells, using a microtiter plate assay. The plates were seeded with cells and... 

Fig. 2. Fluorescence image of surface localization in cultured cells. OVCAR-3 human ovarian cancer cells were incubated with monoclonal antibody Kl, followed by antimouse IgG conjugated to rhodamine as described in the protocol (3). The intense diffuse speckled surface fluorescence image is shown on multiple cells in this area of the culture, with reinforced bright images at the vertical cell margins generating a cobblestone appearance (bar = 4 jm).

Cartee L, Kucera GL (1998) Gemcitabine Induces programmed cell death and activates protein kinase C in BG-1 human ovarian cancer cells. Cancer Chemother Pharmacol 41 403-412... 

Ma J, Maliepaard M, Kolker HJ, Verweij J, Schellens JHM (1998a) Abrogated energy-dependent uptake of cisplatin in a cisplatin-resistant subline of the human ovarian cancer cell line IGROV-1. Cancer Chemother Pharmacol 41 186-192... 

Ma I, Maliepard M, Nooter K, Loos WJ, Kolker HJ, Verweij J, Stoter G, Schellens JHM (1998b) Reduced cellular accumulation of topotecan a novel medianism of resistance in a human ovarian cancer cell line. Br ) Cancer 77 1645-1652 MacFarlane DE, O Donnell PS (1993) Phorbol ester induces apoptosis in HL-60 promyelocytic leukemia cells but not in HL-60 PET mutant. Leukemia 7 1846-1851... 

Vikhanskaya F, Vignati S, Beccaglia P, et al. Inactivation of p53 in a human ovarian cancer cell line increases the sensitivity to paclitaxel by inducing G2/M arrest and apoptosis. Exp Cell Res 1998 241(1) 96-101. 

Giannakakou P, Sackett DL, Kang YK, et al. Paclitaxel-resistant human ovarian cancer cells have mutant beta-tubulins that exhibit impaired paclitaxel-driven polymerization. J Biol Chem 1997 272(27) 17,118-17,125. 

It has been demonstrated that the human myeloid zinc finger (MZF1) (92) functions as a transcription repressor regulating ERCCl transcription in response to cisplatin-induced DNA damage. It was found that MZFl mRNA is constitutively expressed in human ovarian cancer cells. Quantitative PCR in the same cells showed that MZFl mRNA was decreased upon cisplatin exposure (93). Therefore, decreased expression of MZFl is a mechanism to be further investigated. 

Li Q, Gardner K, Zhang L et al. Cisplatin induction of ERCC-1 mRNA expression in A2780/CP70 human ovarian cancer cells. J Biol Chem 1998 273 23419-23425. 

Grunt, T.W., Somay, C., Ellinger, A., Pavelka, M., Dittrich, E. Dittrich, C. (1992) The differential effects of V,V-dimethylformamide and transforming growth factor-pi on a human ovarian cancer cell line (HOC-7). J. cell. Physiol., 151, 13-22... 

Compound 2 inhibited murine and human bone marrow cell colony formation with and ID50 of 0.1-1 pg/ml, with complete inhibition occurring at 10-100 pg/ml. It was found to be more potent than vinblastine or taxol, with an IC50 of 0.23 nM against human ovarian cancer and colon cancer cell lines. Furthermore, dolastatin 10 was shown to be powerfully effective at binding to tubulin, inhibiting polymerization and it also non-competitively inhibits the binding of vinca alkaloids to tubulin,... 

Cao Z, Fang J, Xia C, Shi X, Jiang BEL 2004. 7>aws-3,4,5 -trihydroxystilbene inhibits hypoxia-inducible factor 1 alpha and vascular endothelial growth factor expression in human ovarian cancer cells. Clin Cancer Res 10 5253-5263. 

Kueck A, Opipari AWJr., Griffith KA, Tan L, Choi M, Huang J, Wahl H, Liu JR. 2007. Resveratrol inhibits glucose metabolism in human ovarian cancer cells. Gynecol Oncol 107 450-457. 

Shi M, Cai Q, Yao L, Mao Y, Ming Y, Ouyang G. 2006a. Antiproliferation and apoptosis induced by curcumin in human ovarian cancer cells. Cell Biol Int 30 221— 226. 

Weir NM, Selvendiran K, Kutala VK, Tong L, Vishwanath S, Rajaram M, Tridanda-pani S, Anant S, Kuppusamy P. 2007. Curcumin induces G2/M arrest and apoptosis in cisplatin-resistant human ovarian cancer cells by modulating Akt and p38 MAPK. Cancer Biol Ther 6 178-184. 

Zheng LD, Tong QS, Wu CH. 2006. Growth inhibition and apoptosis inducing mechanisms of curcumin on human ovarian cancer cell line A2780. Chin J Integr Med 12 1. 

Kim CK, Choi EJ, Choi SH, Park JS, Haider KH, Ahn WS (2003) Enhanced p53 gene transfer to human ovarian cancer cells using the cationic nonviral vector, DDC. Gynecol Oncol 90 265-272... 

In this study, A121a human ovarian cancer cells were incubated with low dose paclitaxel in four levels 0.2, 0.8, 2, and 5 ng/mL respectively at 37 °C. Cells were harvested at five time points of 10, 30, 60, 180, and 360 min. The cells were lysated... 

In general, Ru11 and Os11 arene complexes show promising cytotoxic activity against human ovarian cancer cell lines, some of them as potent as cisplatin and carboplatin. Some structure-activity relationships have been established... 

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