Aplysia punctata

The polyhalogenated monoterpenes 57-59 from the Spanish sea hare Aplysia punctata show identical cytotoxic properties against P-388 mice lymphoma and HT-29 human colon carcinoma (ED50 2.5 pg/ml), A-549 human lung carcinoma and MEL-28 human melanoma cell lines (ED50 1.5 pg/ml) [57]. 

In the lipid extracts of Aplysia punctata, Archidoris britannica, and Coryphella rufubranchialis, sulfatides were detected by paper chromatography.77... 

Ortega MJ, Zubia E, Salva J (1997) New Polyhalogenated Monoterpenes from the Sea Hare Aplysia punctata. J Nat Prod 60 482... 

Quifioa E, Castedo L, Riguera R (1989) The Halogenated Monoterpenes of Aplysia punctata. A Comparative Study. Comp Biochem Physiol 92B 99... 

Findlay JA, Li G (2002) Novel Terpenoids from the Sea Hare Aplysia punctata. Can J Chem 80 1697... 

In order to confirm the biotransformation capability of the sea hare -Aplysia punctata, Quinoa et al. (46) studied a number of marine algae for the presence of halogenated monoteipenes and compared the hplc and gc profiles of the extracts of the hepatopancreas of A. punctata with algal extracts. The results of this study showed a direct correlation between the chromatographic and gc-ms profile of the secondary metabolites of Plocamium coccineum and A. punctata. However, no biotransformation capability was noticed. 

Neoconcinndiol hydroperoxide, which derives from neoconcinndiol by the loss of a bromine atom was (see Figure 13.21) the only hydroperoxyditerpene isolated from a red alga until the discovery in 2005 of a series of six hydroperoxides all having the rare carbon skeleton of dactylomelane in a undetermined Laurencia harvested south of Tenerife, Canary Islands (Fernandez et al., 2005). This discovery is interesting for several reasons because, on the one hand, it shows the presence of a rare functional group on an uncommon carbon skeleton (Kornprobst and Al Easa, 2003) but appears to confirm, on the other hand, that punctatene acetate isolated from the mollusk Aplysia punctata in 2002 would be of food origin (see Chapter 23). ... 

Punctatene isolated from Laurencia and its acetate isolated from Aplysia punctata are not hydroperoxides. All hydroperoxyditerpenes of Laurencia sp. have been named with reference to dactylomelol, isolated from Aplysia dactylomela (see Chapter 23). 

Jimenez, C Quinoa, E Casredo, L and Riguera, R. (1986) Epidioxysterols from the tunicates Dmdrodoa grossularia and Ascididla aspersa and the gastropoda Aplysia depilans and Aplysia punctata. J. Nat. Prod., 49, 905-909. 

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