Hormonal therapy Hormones

If these patients miss an expected menses, they should be tested for pregnancy and discontinue hormone therapy. Hormone therapy must be continued at least until the average age of natural menopause, and longterm follow-up is necessary. 

Hormonal therapy Hormone refractory prostate tumors Somatic missense mutations (e.g. Thr877Ala in exon 1) create tumors refractory to hormonal therapy (60-63)... 

Face creme Inflammation, pain Joint and muscle pain Rheumatoid diseases Venous microcirculation Anti-inflammatory Sport injuries Antimycotic Hormone therapy Hormone therapy... 

Thyroid-stimulating hormone can be used clinically to test thyroid function but has not found practical apphcation in the treatment of human thyroid insufficiency. Direct replacement therapy with thyroid hormone is easy and effective, owing to a simple molecular stmcture. TSH has been used in the veterinary treatment of hypothyroidism, and preparations of TSH ate produced by Cooper Animal Health, Inc. and Armour Pharmaceuticals. 

Modem cancer therapy has been primarily dependent upon surgery, radiotherapy, chemotherapy, and hormonal therapy (72) (see Chemotherapeutics,anticancer Hormones Radiopharmaceuticals). Chemotherapeutic agents maybe able to retard the rate of growth, but are unable to eradicate the entire population of neoplastic cells without significant destmction of normal host tissue. This serious side effect limits general use. More recentiy, the immunotherapeutic approach to cancer has involved modification and exploitation of the cellular and molecular mechanisms in host defense, regulation of tissue proliferation, tissue differentiation, and tissue survival. The results have been more than encouraging. 

Hormonal effects on the aging process have been areas of current interest. The intricacies of the interaction of the various hormones are undoubtedly involved in the aging process and hence these hormones could be called antiaging agents. Both androgens and estrogens have been studied. Low level estrogen replacement therapy (ERT) has been used to treat postmenopausal women. 

Insulin is a peptide hormone, secreted by the pancreas, that regulates glucose metabolism in the body. Insufficient production of insulin or failure of insulin to stimulate target sites in liver, muscle, and adipose tissue leads to the serious metabolic disorder known as diabetes mellitus. Diabetes afflicts millions of people worldwide. Diabetic individuals typically exhibit high levels of glucose in the blood, but insulin injection therapy allows diabetic individuals to maintain normal levels of blood glucose. 

As with the other sex hormones, the first clinical use of Hiidrogens was for support therapy in individuals deficient in the endogenous hormone. The discovery that androgens exert an ana-hnlic effect greatly extended the indications for their use. 

Therapeutic Function Estrogen used in hormone therapy for prostate cancer Chemical Name 4,4 -(1,2-Diethyl-1,1-ethenediyl)bisphenol-bis(dihydrogen phosphate) Common Name Fosfestrol Structural Formula ... 

An endocrine disorder first described by the British Physician Thomas Addison in the mid 1800 s. The adrenal glands fail to produce sufficient amounts of glucocorticoid hormones (cortisol) and sometime mineralocorticoid (aldosterone). If left untreated it is life-threatening, the patient will show muscle weakness, hyperpigmentation and even depression. Typical treatment is hydrocortisone replacement therapy. 

However, despite its enormous importance to human physiology, no pharmacological compounds targeting the components of the circadian clock system have been identified to date. There are, nevertheless, two therapeutic approaches that are currently used for treatment of circadian-related disorders - full-spectrum and bright light therapy and melatonin therapy. Melatonin is a hormone that is produced by the pineal gland in... 

Turgeon JL, McDonnell DP, Martin KA et al (2004) Hormone therapy physiological complexity belies therapeutic simplicity. Science 304 1269-1273... 

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