INDEX hormonal therapy

Sleep apnoea A longitudinal observational study of 50 children (26 female median age 1.9 years at the start of the study) with Prader-Willi syndrome (PWS) was conducted to assess the association between long-term growth hormone therapy, adenotonsillar tissue hypertrophy and obstructive sleep apnoea [21. The nmnber of patients with an obstructive apnoea hypopnoea index (OAHI) > 1 (considered pathological obstructive sleep) increased from 3 to 22,... 

Desmopressin replacement therapy is the first choice. Thiazide diuretics (and chlortalidone) also have paradoxical antidiuretic effect in diabetes insipidus. That this is not due to sodium depletion is suggested by the fact that the nondiuretic thiazide, diazoxide (see Index), also has this effect. It is probable that changes in the proximal renal tubule result in increased reabsorption and in delivery of less sodium and water to the distal tubule, but the mechanism remains incompletely elucidated. Some cases of the nephrogenic form, which is not helped by antidiuretic hormone, may be benefited by a thiazide. 

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