Hormone replacement therapy hyperplasia

Saw palmetto (cabbage palm, fan palm, scrub palm) Serenoa repens %mptoms of benign prostatic hyperplasia Generally well-tolerated occasional gastrointestinal effects May interact with hormones such as oral contraceptive drugs and hormone replacement therapy. 

Hormone replacement therapy PO 5-lOmgfor 12-14 consecutive days a month, beginning on day 1 or 16 of cycle given as parf of regimen with conjugated estrogens. Endometrial hyperplasia PO 2.5-10 mg/day for 14 days. 

Lethaby A, Suckling J, Barlow D, Farquhar CM, Jepson RG, Roberts H. Hormone replacement therapy in postmenopausal women endometrial hyperplasia and irregular bleeding. Cochrane Database Syst Rev 2004 (3) CD000402. 

Note that pituitary enlargement in hypothyroidism does not invariably indicate the presence of a primary pituitary tumor. Pituitary enlargement is seen in patients with severe primary hypothyroidism owing to compensatory hyperplasia and hypertrophy of the thyrotrophs. Serum TSH concentrations and pituitary enlargement decline during thyroid hormone replacement therapy, indicating that the TSH secretion is not autonomous. These patients are easily separated from patients with primary pituitary failure by measuring a TSH level. 

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