Growth hormone therapy and

A 13-month-old girl with Turner s syndrome developed mild papilledema (29). At the age of 4 years she was considered for growth hormone therapy and investigation showed intracranial hypertension before therapy was started. 

Jeffcoate W. Growth hormone therapy and its relationship to insulin resistance, glucose intolerance and diabetes mel-litus a review of recent evidence. Drug Saf 2002 25(3) 199-212. 

Berini J, Spica Russotto V, Castehmovo P, Di Candia S, Gargantini L, Grugni G, et al. Growth hormone therapy and respiratory disorders long-term follow-up in PWS children. J CUn Endocrinol Metab 2013 98(9) E1516-23. 

List the monitoring parameters necessary to assess therapeutic outcomes and adverse effects in patients receiving growth hormone therapy. 

Recombinant growth hormone therapy is the main pharmacologic treatment for growth hormone deficiency in both children and adults. 

P. Brown, C. C. Gajdusek, C. J. Gibbs, and D. N. Asher, Potential epidemic of Creutzfeldt-Jakob disease from human growth hormone therapy, N. Engl. J. Med., 313(12), 728 (1985). 

Chernausek, S.D., K.M. Attie, J.F Cara, R.G. Rosenfeld, and J. Frane, Growth hormone therapy of Turner syndrome the impact of age of estrogen replacement on final height. Genentech, Inc., Collaborative Study Group. J Clin Endocrinol Metab, 2000. 85(7) 2439-45. 

The recurrence rate of intracranial tumors has been addressed in a number of large observational studies. Reports from the NCGS database (which includes 1262 children with brain tumors) and from England have shown no increase in intracranial tumor recurrence in patients treated with growth hormone (97,98). For patients with craniopharyngioma, postoperative irradiation reduced the recurrence rate, but growth hormone therapy did not increase the risk (99). 

Crock PA, McKenzie JD, Nicoll AM, Howard NJ, Cutfield W, Shield LK, Byrne G. Benign intracranial hypertension and recombinant growth hormone therapy in Australia and New Zealand. Acta Paediatr 1998 87(4) 381-6. 

Bareille P, Azcona C, Matthews DR, Conway GS, Stanhope R. Lipid profile, glucose tolerance and insulin sensitivity after more than four years of growth hormone therapy in non-growth hormone deficient adolescents. Clin Endocrinol (Oxf) 1999 51(3) 347-53. 

Wiltshire E, Wickremesekera A, Dixon J. Floating-Harbor syndrome complicated by tethered cord a new association and potential contribution from growth hormone therapy. Am J Med Genet A 2005 136(l) 81-3. 

Leukemia has been reported in a small number of pediatric patients who have been treated with growth hormone, including growth hormone of pituitary origin as well as recombinant DNA origin (somatrem and somatropin). The relationship, if any, between leukemia and growth hormone therapy is unknown... 

K2. Kaiser, F. E., Aging and malnutrition Growth hormone therapy shows promise. Geriatrics 47, 85-90(1992). 

It is used in children with growth hormone deficiency, while the bone epiphyses are still open, to prevent dwarfism and provide normal growth. Use simply to avoid low height for social reasons is controversial, and at 15 000 ( 20 000) p.a. is certainly hard to justify. Growth hormone therapy should be confined to specialist clinics. 

British Medical Journal 319 1343-1345 Vance M L, Mauras N1999 Growth hormone therapy in adults and children. New England Journal of Medicine 341 1206-1216 Vessey M P et al 1989 Mortality among oral... 

Pharmacologic therapy for acromegaly should be considered when surgery and irradiation are contraindicated, when rapid control of symptoms is needed, or when other treatments have failed to normalize growth hormone (GH) and insulin-like growth factor-1 (IGF-I) concentrations. 

Cuttler L, Silvers JB, Singh J, et al. Short stature and growth hormone therapy A national study of physician recommendation patterns. JAMA 1996 276 531-537. 

H20. Hintz, R. L., Liu, F., Rosenfeld, R. G., and Kemp, S. F., Plasma somatomedin-binding proteins in hypopituitarism Changes during growth hormone therapy. /. CUn. Endocrinol. Metab. 53, 100-104 (1981). 

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