Gonadotropin-releasing hormone therapy

Higashijima T, Kataoka A, Nishida T, YakushijiM (1996) Gonadotropin-releasing hormone agonist therapy induces apoptosis in uterine leiomyoma. Eur J Obstet Gynecol Reprod Biol 68 169-173... 

Pierce SJ, Gazvani MR, Farquharson RG. Long-term use of gonadotropin-releasing hormone analogues and hormone replacement therapy in the management of endometriosis a randomized trial with a 6-year follow-up. Fertil Steril 2000 74(5) 964-8. 

Tahara M, Matsuoka T, Yokoi T, Tasaka K, Kurachi H, Murata Y. Treatment of endometriosis with a decreasing dosage of a gonadotropin-releasing hormone agonist (nafarelin) a pilot study with low-dose agonist therapy ( draw-back therapy). Fertil SterU 2000 73(4) 799-804. 

Ovulation suppression (e.g., oral contraceptives, danazol, gonadotropin-releasing hormone agonists) should be used before resorting to surgical therapy in women with severe PMDD. 

Nonsteroidal anti-inflammatory drugs ibuprofen, ketoprofen, naproxen sodium Alternative bromocriptine, danazol, oral contraceptives, gonadotropin releasing hormone agonist estrad iol/progesterone add-back therapy Migraines Caffeine restriction... 

Serotonin reuptake inhibitor (intermittent or continuous with increase in dose during luteal phase) Alternative danazol or gonadotropin-releasing hormone agonist for 2-3 cycles (if longer treatment, estradiol progesterone add-back therapy may be required)... 

Surrey ES. Add-back therapy and gonadotropin-releasing hormone agonists in the treatment of patients with endometriosis Can a consensus be reached Add-Back Consensus Working Group. Fertil Steril 1999 71 420-424. 

Modalities to prevent priapism are limited and not well studied. Pseudoephedrine (30 or 60 mg/day given orally at bedtime) and leuprolide, a gonadotropin-releasing hormone, have been used to decrease the number of recurrent episodes of priapism. Hydroxyurea therapy may also be useful. Recently, low-doses of an antiandrogen, bicalutamide, have been used in two patients with SCD and one patient with spinal cord injury for treatment of recurrent and refractory priapism without major side effects. " " ... 

Gonadotropin releasing hormone G-protein coupled receptor G protein Receptor-30 Hormone replacement therapy Inhibiting concentration for 50 %... 

Buserelin (Suprefact) and leuprolide (Lupron) are peptide analogues of the hypothalamic hormone LH-RH (luteinizing hormone-releasing hormone). Chronic exposure of the pituitary to these agents abolishes gonadotropin release and results in markedly decreased estrogen and testosterone production by the gonads. Their major clinical use is in the palliative hormonal therapy of cancer of the prostate. 

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