Zoladex. hormonal therapy

Moghissi KS, Schlaff WD, Olive DL, Skinner MA, Yin H. Goserelin acetate (Zoladex) with or without hormone replacement therapy for the treatment of endometriosis. Fertil Steril 1998 69(6) 1056-62. 

The biggest success of pol5mier controlled release systems in cancer therapy however has been in the area of prostate cancer treatment. This therapy is luiique since it uses a hormone-suppressant rather than a chemotherapeutic agent to minimize cancer cell growth in the prostate. Several products include Lupron Depot (TAP Pharmaceuticals), Zoladex (Astra-Zeneca), and Trelstar Depot (Debio RP, Pharmacia). Lupron Depot involves PLA microspheres, Zoladex formulation is an extruded rod, whereas Trelstar depot consists of PLGA microspheres, all of which incorporate LHRH analogues. 

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