High risk

Despite such improvements, exploration remains a high risk activity. Many international oil and gas companies have large portfolios of exploration interests, each with their own geological and fiscal characteristics and with differing probabilities of finding oil or gas. Managing such exploration assets and associated operations in many countries represents a major task. 

Case 4 has a high risk of failure (85%) to find any oil, buf if there is oil there then the volume in place might be quite large (up to 400 MMstb). This would class as a high risk, high reward prospect. 

Biorational approaches have proven useful in the development of classes of herbicides which inhibit essential metaboHc pathways common to all plants and thus are specific to plants and have low toxicity to mammalian species. Biorational herbicide development remains a high risk endeavor since promising high activities observed in the laboratory may be nullified by factors such as limitations in plant uptake and translocation, and the instabiHty or inactivity of biochemical en2yme inhibitors under the harsher environmental conditions in the field. Despite these recogni2ed drawbacks, biorational design of herbicides has shown sufficient potential to make the study of herbicide modes of action an important and growing research area. 

Although most nickel sensitization results from nonoccupational exposures, nickel dermatitis was historically a problem in workplaces where there was a high risk of continuous contact with soluble nickel, eg, in electroplating (qv) shops. Improved personal and industrial hygiene has largely eliminated this problem. However, there are a few occupations involving wet nickel work, particularly where detergents faciUtate the penetration of skin by nickel, where hand eczema may occur (126). 

Respiratory Syncytial Virus. Respiratory syncytial vims (RSV) causes severe lower respiratory tract disease in infants. It is the major cause of hospitalization in the United States (- 90,000 events/yr) and it has a high mortaUty rate in neonates and other high risk populations, such as the geriatric population (51). Development of an RSV vaccine has always been a major priority, however, earlier attempts have mostiy failed (70). 

Both amantadiae and rknantadiae have been found to reduce the duration of influenza A-iaduced fever and malaise, and to lessen viral shedding. Prophylactic treatment has been recommended for high risk patients (95). It has been suggested that, ia the presence of amantadine, the influenza vims attaches normally to cells, but once iaside the ceU the vims fails to initiate repHcation. Thus amantadine appears to inhibit the initiation of transcription at an early stage between uncoating and viral-specific RNA synthesis (96). 

Since the utility curve has such a subjective basis, most companies prefer the objectivity of (NPV) and (DCFRR) over the range of the normal income and expenditure budget. Subjective methods tend to be reserved for exceptionally high risk projects. 

One test, made at the Radcliffe Infirmary in Oxford, " identified two areas of the UK in which the incidence of stomach cancer was particularly high and two in which it was particularly low. People attending hospitals in these areas as visitors rather than patients were asked to provide samples of saliva. The hypothesis suggested that samples from the high-risk areas should contain more nitrite and nitrate than those from the low-risk areas, but this was not so. The samples from the low-risk populations had nitrate concentrations 50% greater than those from the high-risk areas. 

The power factor can be improved with the use of shunt capacitors at the load points or at the receiving end, as discussed above. It is not practical to have a near-fixed loading for all hours of the day. Moreover, there may also be seasonal loads which may upset the parameters considered while installing the capacitor banks. In such conditions the system may therefore have to be underutilized or run under a high risk of instability during... 

Helps to identify items that are of high risk through the ealeulation of the Risk Priority Number (RPN), and so gives a means of deeiding priorities for eorreetive aetion... 

Carbon dioxide is useful where the minimum damage should be eaused to the materials at risk, on fires in liquid, solids or eleetrieal fires but not where there is a high risk of reignition. It is likely to be ineffeetive outdoors due to rapid dispersal. It is unsuitable for reaetive metals, metal hydrides or materials with their own oxygen supply, e.g. eellulose nitrate. 

Lin, D., A. Mittelman, V. Halpin, and D. Cannon (1994). Inherently Safer Chemistry A Cuide to Current Industrial Processes to Address High Risk Chemicals. Washington, DC Office of Pollution Prevention and Toxics, U. S. Environmental Protection Agency. 

One of the products of a nuclear power plant PSA is a list of plant responses to initiating events (accident starters) and the sequences of events that could follow. By evaluating the significance of the identified risk contributors, it is possible to identify the high-risk accident. sequences and take actions to mitigate them. 

Although the consequences of the high-risk accident sequences may vary from one PSA to another, all PSAs attempt to evaluate realistically, the consequences of hypothetical accident sequences. Expending on the scope of the PSA, these evaluations may include an estimation of the number of latent cancers, the number of immediate fatalities, the probability of core damage, or a number of other consequence measures. 

Prioritize Safety Improvements. This uses the detailed analysis (2) to identify items having high risk importance. Engineering analysis identifies and costs candidate improvements which are selected on the bn. o of risk reduction for a given cost. ... 

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