Respiratory syncytial vims

Respiratory Syncytial Virus. Respiratory syncytial vims (RSV) causes severe lower respiratory tract disease in infants. It is the major cause of hospitalization in the United States (- 90,000 events/yr) and it has a high mortaUty rate in neonates and other high risk populations, such as the geriatric population (51). Development of an RSV vaccine has always been a major priority, however, earlier attempts have mostiy failed (70). 

An infant with severe respiratory syncytial vims (RSV) bronchiolitis is best treated with... 

Doner, T., Dundrarova, D., Teparicharova, I.. Orozeva, M., Bustandzieva, R., Mitor, B. Choice of cryoprotective media and freeze-drying parameters of bovine corona-virus and respiratory syncytial vims. IV. International School Cryobiology and Freeze-Drying p. 31,32, Sofia, 1989... 

Doner et al. [3.26] studied bovine corona vims (BCV) and respiratory syncytial vims (RSV). Both can be frozen without CPAs at0.2-0.3 °C/min with no loss of titer. Faster freezing (0.4—30 °C/min) results in an increasing loss of titer of 1-3 decades. The... 

The Impact-RSV Study Group. Palivizumab, a humanized respiratory syncytial vims monoclonal antibody, reduces hospitalization from respiratory syncytial vims infection in high-risk infants. Pediatrics 1998 102 531-537. 

Glezen WP, Taber LH, Frank AL, Kasel JA (1986) Risk of primary infection and reinfection with respiratory syncytial vims. Am J Dis Child 140 543-546... 

Anderson LJ, Parker RA, Strikas RL (1990) Association between respiratory syncytial vims outbreaks and lower respiratory tract deaths of infants and young children. J Infect Dis 161 640-646... 

Nicholson KG (1996) Impact of influenza and respiratory syncytial vims on mortality in England and Wales form January 1975 to December 1990. Epidemiol Infect 116 51-63... 

Thompson WW, Shay DK, Weintraub E et al (2003) Mortality associated with influenza and respiratory syncytial vims in the United States. JAMA 289 179-186... 

Englund JA, Sullivan CJ, Jordan MC et al (1988) Respiratory syncytial vims infection in immunocompromised adults. Ann Intern Med 109 203-208... 

HIS. Horasleth, A., Aean, K., and Gundestrup, M., Detection of respiratory syncytial vims and rotavims by enhanced chemiluminescence enzyme-linked immunosorbent assay. J. Clin. Microbiol. 26, 630-635 (1988). 

Infant respiratory distress syndrome Cutaneous T-cell lymphoma Respiratory syncytial vims lower respiratory tract infections... 

The antiviral actions of ribavirin include inhibition of RNA polymerases, inhibition of DNA and RNA synthesis, and interference with viral coating. Ribavirin is used by aerosol inhalation for respiratory syncytial vims infections in premature infants and children with cardiopulmonary disease. The answer is (D). 

Respiratory syncytial vims RSV immune globulin Palivizumab usually preferred... 

Collins, P.L., McIntosh, K. and Chanock, R.M., 1996, Respiratory syncytial vims. In Fields -Virology (B.N. Fields, D.N. Knipe and P.M. Howley, eds), Lippincott-Raven, Philadelphia, pp. 1313-1351. 

Klinguer-Hamour, C., Libon, C., Plotnicky-Gilquin, H., Bussat, M.C., Revy, L., Nguyen, T., Bormefoy, J.Y., Corvai a, N. and Beck, A., 2002, DDA adjuvant induces a mixed Thl/Th2 immune response when associated with BBG2Na, a respiratory syncytial vims potential vaccine. Faccwe 20 2743-2751. 

Tripp RA, Jones LP, Haynes LM et al. CX3C chemokine mimicry by respiratory syncytial vims G glycoprotein. Nat Immunol 2001 2(8) 732-8. 

Noah TL, Becker S. Respiratory syncytial vims-induced cytokine production by a human bronchial epithelial cell line. Am J Physiol 1993 265(5 Pt l) L472-8. 

O Donnell D R, Milligan L, Stark JM. Induction of CD95 (Fas) and apoptosis in respiratory epithelial cell cultures following respiratory syncytial vims infection. Virology 1999 257(1) 198-207. 

Hickling TP, Bright H, Wing K et al. A recombinant trimeric surfactant protein D carbohydrate recognition domain inhibits respiratory syncytial vims infection in vitro and in vivo. Eur J Immunol 1999 29(ll) 3478-84. 

Schlender J, Walliser G, Fricke J et al. Respiratory syncytial vims fusion protein mediates inhibition of mitogen-induced T-cell proliferation by contact. J Virol 2002 76(3) 163-70. 

Tripp RA, Moore D, Jones L et al. Respiratory syncytial vims G and/or SH protein alters Thl cytokines, natural killer cells, and neutrophils responding to pulmonary infection in BALB/c mice. 

Tripp RA, Jones L, Anderson LJ. Respiratory syncytial vims G and/or SH glycoproteins modify CC and CXC chemokine mRNA expression in the BALB/c mouse. J Virol 2000 74(13) 6227 9-... 

Chen JL, Blanc P, Stoddart CA, Bogan M, Rozhon EJ, Parkeinson N, Ye Z, Cooper R, Balick M, Nanakom W, Keman MR (1998) New iridoids from the medicinal plant Barleria prionitis with potent activity against respiratory syncytial vims. J Nat Prod 61 1295-1297... 

In another related study, investigation of some Icelandic lichens resulted in the identification of two compounds possessing antiviral activities against three vimses respiratory syncytial vims (RSV), herpes vims 1, and herpes vims 2. Activity against herpes vimses 1 and 2 was less potent than activity against RSV. The... 

Respiratory syncytial vims (RSV) is a major cause of mortality in yoimg infants and the elderly. The mechanism of action of ribavirin is not entirely clear although it is probable that it acts as an inhibitor of inosine dehydrogenase which is involved in the introduction of a carbonyl group into the inosine stmcture en route to the synthesis of gua-nosine triphosphate (GTP). GTP is required for viral RNA transcription. Ribavirin may also interfere with the action of the viral RNA polymerase. There is some debate over the effectiveness of ribavirin in treating RSV. It is also used in combination with interferon in the treatment of hepatitis C. RSV is also treated with monoclonal antibody therapy and this is discussed in the Chapter 26. 

Wyde PR. Respiratory syncytial vims (RSV) disease and prospects for its control. Antiviral Res. 1998 29 63-79. 

Respiratory syncytial vims is another member of the Paramyxoviridae family of viruses that has been considered for new vector development. RS V mediates cell entry through its glycoproteins G and F (215). Like SeV, transcription and replication are cystoplasmic events. In preliminary studies, a replication-competent RSV-GFP virus eflSciently transduced WD FIAE cells following apical, but not basolateial, application of vector (203). RS V will likely have similar limitations as SeV for vector development. However, SeV and RSV offer exciting promise for future human airway gene transfer efforts. 

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