Herpes simplex virus thymidine kinase gene

Pelham, H.R.B. Bienz, M. (1982). A synthetic heat-shock promoter element confers heat-inducibility on the herpes simplex virus thymidine kinase gene. EM BO Journal, 1,1473-7. 

Goto, T., Nishi, T., Tamura, T., Dev, S.B., Takeshima, H., Kochi, M., Yoshizato, K., Kuratsu, J., Sakata, T., Hofmann, G.A. and Ushio, Y. (2000) Highly efficient electro-gene therapy of solid tumor by using an expression plasmid for the herpes simplex virus thymidine kinase gene. Proc. Natl. Acad. Sci. USA, 97, 354-359. 

Vile, R.G. and Hart, I.R. (1993) Use of tissue-specific expression of the herpes simplex virus thymidine kinase gene to inhibit growth of established murine melanomas following direct intratumoral injection of DNA. Cancer Res., 53, 3860-3864. 

Fillat, C., Carrio, M., Cascante, A., and Sangro, B. Suicide gene therapy mediated by the herpes simplex virus thymidine kinase gene/ganciclovir system Fifteen years of application. Curr. Gene. Ther. 3 13-26, 2003. 

R. D. Alvarez, G. P. Siegal, J. T. Douglas, and D. T. Curiel, Basic fibroblast growth factor enhancement of adenovirus-mediated delivery of the herpes simplex virus thymidine kinase gene results in augmented therapeutic benefit in a murine model of ovarian cancer, Clin. Cancer Res. 4 2455 (1998). 

A. Ido, K. Nakata, Y. Kato, K. Nakao, K. Murata, M. Fujita, N. Ishii, T. Tamaoki, H. Shiku, and S. Nagataki, Gene therapy for hepatoma cells using a retrovirus vector carrying herpes simplex virus thymidine kinase gene under the control of human alpha-fetoprotein gene promoter, Cancer Res. 55 3105 (1995). 

T. Osaki, Y. Tanio, I. Tachibana, S. Hosoe, T. Kumagai, I. Kawase, S. Oikawa, and T. Kishimoto, Gene therapy for carcinoembryonic antigen-producing human lung cancer cells by cell type-specific expression of herpes simplex virus thymidine kinase gene, Cancer Res. 54 5258 (1994). 

T. Joki, M. Nakamura, and T. Ohno, Activation of the radiosensitive EGR-1 promoter induces expression of the herpes simplex virus thymidine kinase gene and sensitivity of human glioma cells to ganciclovir, Hum. Gene Ther. 6 1507 (1995). 

D. Vandier, O. Rixe, M. Brenner, A. Gouyette, and F. Besnard, Selective killing of glioma cell lines using an astrocyte-specific expression of the herpes simplex virus-thymidine kinase gene, Cancer Res. 58 4577 (1998). 

Elshami, A. A., Kucharczuk, J. C., Zhang, H. B., Smythe, W. R., Hwang, H. C., Litzky, L. A., Kaiser, L. R. and Albelda, S. M. (1996). Treatment of pleural mesothelioma in an immunocompetent rat model utilizing adenoviral transfer of the herpes simplex virus thymidine kinase gene. Hum. Gene Ther. 7, 141-148. 

Mizuno, M. et al. (1998). Adeno-associated virus vector containing the herpes simplex virus thymidine kinase gene causes complete regression of intrace-rebrally implanted human gliomas in mice, in conjunction with ganciclovir administration. Jpn. J. Cancer Res. 89(1), 76-80. 

Haj-Ahmad Y, Graham FL. 1986. Development of a helper-independent human adenovirus vector and its use in the transfer of the herpes simplex virus thymidine kinase gene. J. Virol. 57 267-74... 

Tabin CJ, Hoffman JW, Goff SP, Weinberg RA. Adaptation of a retrovirus as a eucaiyotic veetor transmitting the herpes simplex virus thymidine kinase gene. Mol Cell Biol 1982 2 426 36. 

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