Herpes simplex thymidine kinase

Ishii Morita, H., Agbaria, R., Mullan, C.A., Hirano, H., Koeplin, D.A., Ram, Z., Oldfield, E.H., lohns, D.G., and Blaese, R.M., Mechanism of bystander effect killing in the herpes simplex thymidine kinase gene therapy model of cancer treatment, Gene Therapy, 1997, 4, 244—251. 

Shimotohno K, Temin HM (1981), Formation of infectious progeny virus after insertion of herpes simplex thymidine kinase gene into DNA of an avian retrovirus, Cell 26 67-77. 

Voges, J., Weber, F., Reszka, R., Sturm, V., Jacobs, A., Heiss, W. D., Wiestler, O., and Kapp, J. F. (2002), Clinical protocol Liposomal gene therapy with the herpes simplex thymidine kinase gene/ganciclovir system for the treatment of glioblastoma multiforme, Hum. Gene Ther., 13, 675-685. 

Gene Therapy for the Treatment of Recurrent Pediatric Malignant Astrocytomas with In Vivo Tumor Transduction with the Herpes Simplex-Thymidine Kinase Gene... 

Lanuti M, Gao G P, Force S D, et al. (1999). Evaluation of an ElE4-deleted adenovirus expressing the herpes simplex thymidine kinase suicide gene in cancer gene therapy. Human Gene Ther. 10 463-475. 

Sandmair AM, Vapalahti M, Yla-Herttuala S. Adenovirus-mediated herpes simplex thymidine kinase gene therapy for brain tumors. Adv Exp Med Biol 2000 465 163-170. 

The production of selectable vectors for use in animals cells often used Szybalski s system or further developments based on selective protocols directed to the purine synthesis pathway, for example, Bacchetti and Graham [198], who transferred the Herpes simplex thymidine kinase into a human cell line, albeit with very low efficiency in 1977 and Mulligan and Berg [199] who developed a selection protocol for the expression of an E. coli gpt gene in a eukaryotic vector in 1981. 

Lambright ES, Amin K, Wiewrodt R, Force SD, Lanuli M Propert KJ, Kaiser LR, and Albelda SM. Inclusion of the herpes simplex thymidine kinase gene in a replicating adenovims does not augment antitumor efQcacy. Gene Ther 2001 8 946-953. 

Shatma S, Miller P, Stolina M, et al. Multi-component gene therapy vaccines for lung cancer effective eradication of established murine tumors in vivo with interleukin 7/herpes simplex thymidine kinase-transduced autologous tumor and ex vivo-activated dendritic cells. Gene Ther 1997 4 1361-1370. 

Replication-competent viral HSV-l mutants (HSV-1716) lytic therapy Herpes simplex thymidine kinase Tumor-restricted viral replication and cytotoxicity Protocol pending... 

Smythe WR, Hwang HC, Elshami AA, Amin K, Eck S, Davidson B, Wilson J, Kaiser ER, Albelda SM. Successful treatment of experimental human mesothelioma using adenovirus transfer of the herpes simplex-thymidine kinase gene. Ann Surg 1995 222 78-86. 

Kucharczuk JC, Raper S, Elshami AA, Amin K, Sterman DH, Litzky LA, Kaiser LR, Albelda SM. Safety of adenoviral-mediated transfer of the herpes simplex thymidine kinase cDNA to the pleural cavity of rats and non-human primates. Hum Gene Ther 1996 7 2225-2233. 

Coll J, Mesnil M, Lefebvre M, Lancon A Favrot M. Long-term survival of immunocompetent rats with intiapeiitoneal colon carcinoma tumors using herpes simplex thymidine kinase/ganciclovir and IL-2 treatments. Gene Ther 1997 4 1160-1166. 

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