Helicobacter duodenal ulcer

The proton pump inhibitors are particularly important in the treatment of Helicobacter pylori in patients with active duodenal ulcers. Helicobacter pylori (H. pylori) has been implicated as a causative organism in a type of chronic gastritis and in a large number of cases of peptic and duodenal ulcers. 

Excessive secretion of gastric acid, associated with Helicobacter pylori infection, can result in the development of gastric and duodenal ulcers small changes in the composition of bile can result in crystallization of cholesterol as gallstones failure of exocrine pancreatic secretion (as in cystic fibrosis) leads to undernutrition... 

Wyatt, J.I. (1992). Helicobacter pylori, duodenitis and duodenal ulceration. In Helicobacter pylori, and Gastroduodenal Disease (eds B.J. Rathbone and R.V. Heatley) pp. 140-149. Blackwell Scientific Publications, Oxford. 

Losec (omeprazole) Duodenal ulcer Gastro-oesophageal reflux Helicobacter infections 5.7 1.9 1989 - UK and US Once daily, except when used as part of combination therapy... 

Leodolter A, Kulig M, Brasch H, Meyer-Sabellek W, Willich SN, Malfertheiner P A meta-analysis comparing eradication, healing and relapse rates in patients with Helicobacter pylori-associated gastric or duodenal ulcer. Aliment Pharmacol Ther 2001 15 1949-1958. 

Helicobacter pylori to human gastric epithelium.26 Clinical studies have identified H. pylori as a causative agent in gastric and duodenal ulcers.27 Considerable evidence exists to suggest that carbohydrate-based treatments could be an effective means to combat infection.28 Since bacterial attachment is a prerequisite to infection,29 soluble Leb oligosaccharides may serve as therapeutic alternatives to broad-spectrum antibiotics. 

Rauws, E. A., and Tytgat, G. N. (1990) Cure of duodenal ulcer associated with eradication of Helicobacter pylori. Lancet. 335, 1233-1235. 

Duodenal ulcer associated with Helicobacter pylori n combination with antibiotics)... 

Helicobacter pylori H. pylori is found in approximately 100% of chronic active antral gastritis cases, 90% to 95% of duodenal ulcer patients, and 50% to 80% of gastric ulcer patients. The treatment of documented H. pylori infection in patients with confirmed peptic ulcer on first presentation or recurrence has been recommended by the National Institutes for Health in a 1994 Consensus Conference. Once H. py/on eradication has been achieved, reinfection rates are less than 0.5% per year, and ulcer recurrence rates are dramatically reduced. 

Vondracek TG. Ranitidine bismuth citrate in the treatment of Helicobacter pylori infection and duodenal ulcer. Ann Pharmacother 1998 32(6) 672-9. 

Duodenal ulcer caused by Helicobacter pyhri. PO 40 mg (esomeprazole) once a day, with amoxicillin 1000 mg and clarithromycin 500 mg twice a day for 10 days. 

Healed duodenal ulcer, gastroesophageal reflux disease PO 15 mg/day Helicobacter pylori infection PO (Triple drug therapy) 30mgql2hfor 1 OH 4 days. PO (Dual drug therapy) 30 mg q8h for 14 days. 

Helicobacter pylori duodenal ulcer PO 20 mg once daily or 40 mg/day as a single or in 2 divided doses in combination therapy with antibiotics. Dose varies with regimen used. 

Duodenal ulcers associated with Helicobacter pybri infection PO 400 mg twice a day for 4 weeks in combination with clarithromycin 500 mg 2-3 times a day for the first 2 weeks. 

G.M. Forbes, et al., Duodenal ulcer treated with Helicobacter pylori eradication Seven year follow-up. Lancet 343 288-360, 1994. 

A new potential for antibiotics is the treatment of ulcers caused by Helicobacter pylori. Hundreds of millions of people throughout the world are infected with this Gram-negative bacterium which causes most gastric and duodenal ulcers. Broths of an actinomycete, Amycolata sp., were reported to contain eight novel quiniolones which inhibit Helicobacter pylori at 0.1 ng/ml while not inhibiting other bacteria. ... 

Bismuth chelate is used for benign gastric and duodenal ulcer and has a therapeutic efficacy approximately equivalent to histamine receptor antagonists. Ulcers remain healed for longer after bismuth chelate than after the histamine receptor antagonists, and this may relate to the ability of the former but not the latter to eradicate Helicobacter pylori. 

Peptic ulcer is not cirrhosis-related. Duodenal ulcers are more common than gastric ulcers. Frequency of peptic ulceration in cirrhotic patients is about 8-10%, although 60—70% of these cases are as)miptomatic. Gastric ulcers heal more slowly and recur more frequently than in non-drrhotic patients. (55) This condition may be caused by chronic alcohol abuse, portal hypertension or Helicobacter pylori infection (40—50%, with elevated gastrin in the serum). (134, 205) Mallory-Weiss syndrome is often associated with cirrhosis, but there is in fact no causal relationship between the two. Gastroparesis with delayed gastric emptying is frequently observed. (190)... 

Aluminium hydroxide can have an aggravating effect on Helicobacter py/on -associated gastritis in patients with duodenal ulceration (49). 

The efficacy of triple therapy with bismuth plus amoxicillin and metronidazole has been assessed in an open trial in 26 children with duodenal ulcers associated with H. pylori (15). Helicobacter pylori was eradicated in 25 children and the ulcer was healed in 24. During a mean follow-up of nearly 2 years, the annual ulcer relapse rate was 9% (compared with 56% in historical controls, in whom the infection was not eradicated). Adverse events were reported by 13% of the children, and included diarrhea, dizziness, nausea, and vomiting. 

Zanten SJ, Bradette M, Farley A, Leddin D, Lind T, Unge P, Bayerdorffer E, Spiller RC, O Morain C, Sipponen P, Wrangstadh M, Zeijlon L, Sinclair P. The DU-MACH study eradication of Helicobacter pylori and ulcer healing in patients with acute duodenal ulcer using... 

Huang FC, Chang MH, Hsu HY, Lee PI, Shun CT. Longterm follow-up of duodenal ulcer in children before and after eradication of Helicobacter pylori. J Pediatr Gastroenterol Nutr 1999 28(l) 76-80. 

Laine L, Suchower L, Frantz J, Connors A, NeU G. Twice-daily, 10-day triple therapy with omeprazole, amoxicillin, and clarithromycin for Helicobacter pylori eradication in duodenal ulcer disease results of three multicenter, double-blind, United States trials. Am J Gastroenterol 1998 93(11) 2106-12. 

Kim JG, Graham DY. Helicobacter pylori infection and development of gastric or duodenal ulcer in arthritic patients receiving chronic NSAID therapy. The Misoprostol Study Group. Am J Gastroenterol 1994 89(2) 203-7. 

Santolaria S, Lanas A, Benito R, Perez-Aisa M, Montoro M, Sainz R. Helicobacter pylori infection is a protective factor for bleeding gastric ulcers but not for bleeding duodenal ulcers in NSAID users. Aliment Pharmacol Ther 1999 13(11) 1511-18. 

Graham DY. Critical effect of Helicobacter pylori infection on the effectiveness of omeprazole for prevention of gastric or duodenal ulcers among chronic NSAID users. Helicobacter 2002 7(l) l-8. 

El-Omar EM, Penman ID, Ardill JES, Chittajallu RS, Howie C, McCoU KEL. Helicobacter pylori infection and abnormalities of acid secretion in patients with duodenal ulcer disease. Gastroenterology 1995 109 681-91. 

Losec (omeprazole) Duodenal ulcer Gastroesophageal reflux Helicobacter infections 5.7... 

Peptic ulcer disease is associated with Helicobacter pylori infection in 90% of patients with gastric and duodenal ulceration. Elimination of H. pylori infection with antibiotics heals the peptic ulcer and the associated symptoms. Combination therapy with antibiotics, anti-secretory agents, namely H2-receptor antagonists or proton pump inhibitors, and bismuth salts has significantly improved the clinical outcome of peptic ulcer disease. Not all strains of H. pylori cause peptic ulcer disease, and other factors are necessary for H. pylori colonization and disease to occur. Flagellated motile bacteria resist peristalsis and adhere to gastric epithelium in a highly specific manner. 

FIGURE 33-2. The natural history of Helicobacter pylori infection in the pathogenesis of gastric ulcer and duodenal ulcer, mucosa-associated lymphoid tissue (MALT) lymphoma, and gastric cancer. 

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