Human gastric epithelium

Helicobacter pylori to human gastric epithelium.26 Clinical studies have identified H. pylori as a causative agent in gastric and duodenal ulcers.27 Considerable evidence exists to suggest that carbohydrate-based treatments could be an effective means to combat infection.28 Since bacterial attachment is a prerequisite to infection,29 soluble Leb oligosaccharides may serve as therapeutic alternatives to broad-spectrum antibiotics. 

Mahdavi, J., Boren, T., Vandenbroucke-Graula, C., and AppehneUc, B. J. (2003). Limited role of lipopolysaccharide Lewis antigens in adherence of Helicobacter pylori to the human gastric epithelium. Infect. Immun. 71, 2876-2880. 

Strassburg CP, Nguyen N, Manns MP, et al. Polymorphic expression of the UDP-glucuronosyltransferase UGT1A gene locus in human gastric epithelium. Mol Pharmacol 1998 54(4) 647-654. 

Abstract Persistent colonization of the human stomach by Helicobacter pylori is a risk factor for the development of peptic ulcer disease and gastric cancer. Adhesion of microbes to the target tissue is an important determinant for successful initiation, establishment and maintenance of infection, and a variety of different candidate carbohydrate receptors for H. pylori have been identified. Here the different the binding specifities, and their potential role in adhesion to human gastric epithelium are described. Finally, recent findings on the roles of sialic acid binding SabA adhesin in interactions with human neutrophils and erythrocytes are discussed. 

Rubin W, Ross LL, Sleisenger MH, et al. The normal human gastric epithelium. Lab Invest 19 598-626, 1968. 

Crowe SE, Alvarez L, Dytoc H, Hunt RH, Muller M, Sherman P et al (1995) Expression of interleukin 8 and CD54 by human gastric epithelium after Helicobacter pylori infection in vitro. Gastroenterology 108 65-74... 

Mauch F, Bode G, Ditschuneit H, Malfertheiner P (1993) Demonstration of a phospho-lipidrich zone in the human gastric epithelium damaged by Helicobacter pylori Gastroenterology 105 1698-1704... 

Boren T, Falk P, Roth KA, Larson G, Normark S (1993) Attachment of Helicobacter pylori to human gastric epithelium mediated by blood group antigens. Science 262 1892-1895... 

P. Falk, K.A. Roth, T. Boren, U. Westblom, J.I. Gordon, S. Normark, An in vitro adherence assay reveals that Helicobacter pylori exhibits cell lineage-specific tropism in the human gastric epithelium, Proc. Natl Acad. Sci. USA, 1993, 90, 2035-2039. 

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