Goodpasture’s disease

Nitrofurantion D-Penicillamine Peripheral neuritis Autoimmunity drug-induced SLE, myasthenia gravis, pemphigus, glomerulonephritis, Goodpasture s disease... 

II, Cytotoxic Cephalosporine hemolytic anemia Quinidine thrombocytopenia IgG, IgM Hemolytic anemia, Goodpasture s disease IgG and IgM bind to cells (e.g., RBCs), fix complement (opsinization), then lyse cells... 

M. Segelmark, T. Hellmark and J. Wieslander, (2003). The prognostic significance in Goodpasture s disease of specificity, titre and affinity of anti-glomerular-basement-membrane antibodies. Nephron Clin. Pract. 94, C59-C68. 

Interstitial nephritis is associated with chronic exposure to heavy metals, while hydrocarbon exposure has been associated epidemiologically with glomerular nephritis, particularly Goodpasture s disease. 

Experimental smdies demonstrated that enteral administration of GBM ameUorates the development of Goodpasture s disease (108) suggesting that oral recombinant oc3 (IV) NCI peptides might restore tolo-ance or prevent disease onset in patients with Alport s syndrome who undCTgo renal transplantation (109). 

Fervenza FC, Terreros D, Boutaud A, et al. Recurrent Goodpasture s disease due to a monoclonal IgA-kappa circulating antibody. Am J Kidney Dis 1999 34(3) 549-555. Maes B, VanwaUeghem J, Ku)fpers D, et al. IgA antiglomemlar basement membrane disease associated with bronchial carcinoma and monoclonal gammopathy. Am J Kidney Dis 1999 33(2) E3. 

Phelps RG, Rees AJ. The HLA complex in Goodpasture s disease a model for analyzing susceptibility to autoimmunity. Kidney Int 1999 56 1638-1653. 

Cairns LS, Phelps RG, Bowie L, et al. The fine specificity and cytokine profile of T-helper cells responsive to the o3 chain of Type IV collagen in Goodpasture s disease. J Am Soc Nephrol 2003 14 2801-2812. 

Turner AN, Rees AJ. Goodpasture s disease and Alport s Syndrome. Annu Rev Med 1996 47 377-386. 

Hematologic diseases autoimmune hemolytic anemia, idiopathic thrombocytopenic purpura, pernicous anemia Kidney disease Goodpasture syndrom, lipoid nephroses, minimal change glomerulonephritis Diseases of the gastrointestinal tract autoimmune chronic active hepatitis, autoimmune atrophic gastritis, Crohn s disease, ulcerative colitis... 

Glomerular diseases (e.g., anti-glomerular basement membrane disease, focal segmental glomerularsclerosis, IgA nephropathy, hemolytic uremic syndrome, systemic lupus erythematosus, Alport s syndrome, amyloidosis, membranous nephropathy, and Goodpasture s syndrome)... 

Goodpasture s syndrome A rare autoimmune disease that can affect the lungs and kidneys. 

Penicillamine onset may be seen in 1 to 3 months, and most responses occur within 6 months. Early adverse effects include skin rash, metallic taste, hypogeusia, stomatitis, anorexia, nausea, vomiting, and dyspepsia. Glomerulonephritis may occur, which manifests as proteinuria and hematuria. Penicillamine is usually reserved for patients who are resistant to other therapies because of the rare but potentially serious induction of autoimmune diseases (e.g., Goodpasture s syndrome, myasthenia gravis). 

Advantage is taken of the properties of antimctabolitcs in chemotherapy. In cancer chemotherapy, several antimetabolites are used. These include methotrexate, 6-mercaptopunne, 6-thioguanine, 5-fluorouracil, and cystine arabinoside. In the chemotherapy of metastatic breast cancer, 5-fluorouracil and methotrexate, in combination with cyclophosphamide, have been used. Antimetabolites, sometimes along with corticosteroids, are used in the therapy of various autoimmune diseases, such as thrombocytenic purpura, thyroiditis, Goodpasture s syndrome, among others. 

Anemia may result from other complications even when iron supply is sufficient. A decrease in hemoglobin synthesis, a fault in transport mechanisms or destruction of erythrocytes have all been noted. Sideroblastic or iron-loading anemias are characterized by a fault in iron metabolism (see Section 62.2.3.2). There are also several other syndromes of iron deficiency known clinically, including pica and Goodpasture s syndrome (an immune-related lung and kidney disease). The different categories of anemia have been discussed in detail by Prasad.48... 

Nakamura, A., T. Yuasa, A. Ujike, M. Ono, T. Nukiwa, J. V. Ravetch, and T. Takai. 2000. Fcgamma receptor IIB-deficient mice develop Goodpasture s syndrome upon immunization with type IV collagen a novel murine model for autoimmune glomerular basement membrane disease. J. Exp. Med. 191 899-906. 

A 20-year-old man had had Goodpasture s syndrome for 2.5 years, end-stage renal disease on chronic hemodialysis for 15 months, and hypertension controlled... 

Grave s disease (thyrotoxicosis) Hashimoto s thyroiditis Pernicious anaemia Addison s disease Diabetes Type 1 Goodpasture s syndrome Myasthenia gravis Multiple sclerosis ... 

Inhalant abuse can result in kidney stones, severe kidney damage, and acute kidney failure. Electrolyte imbalances can occur in the kidneys and individuals may have difficulties urinating. In severely affected patients, this results in mental confusion, muscle weakness, nausea, and vomiting. Goodpasture s syndrome and glomerulonephritis, a chronic form of kidney disease, may also occur. 

Early hypersensitivity reactions are usually transient, and although there is undoubtedly an increased risk, in patients with a history of previous adverse reactions to penicillamine (or gold), re-exposure may not be followed by a relapse (SEDA-10, 218). In the case of serious complications, such as agranulocytosis, profound thrombocytopenia, polymyositis, or Goodpasture s syndrome, the repeated use of penicillamine carries unacceptable risks. Commencing penicillamine in patients with Wilson s disease can aggravate or even precipitate neurological involvement. 

Sternlieb I, Bennet B, Scheinberg lEI. D-penicillamine induced Goodpasture s syndrome in Wilson s disease. Ann Intern Med 1975 82 673. 

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