Drug-induced autoimmunity

Nitrofurantion D-Penicillamine Peripheral neuritis Autoimmunity drug-induced SLE, myasthenia gravis, pemphigus, glomerulonephritis, Goodpasture s disease... 

Propranolol Procainamide Pyrithioxine Autoimmunity Autoimmunity, drug-induced SLE, rash, vasculitis, myalgias Pemphigus... 

Keywords Cytokines Immune-mediated adverse drug reactions induced autoimmunity Drug-induced liver injury... 

Evaluate other possible causes space-occupying lesion (which may or may not be malignant), drug-induced CNS disease, autoimmune disease, and trauma.8,9... 

Alkaline phosphatase levels and GGT are elevated in plasma with obstructive disorders that disrupt the flow of bile from hepatocytes to the bile ducts or from the biliary tree to the intestines in condition such as primary biliary cirrhosis, sclerosing cholangitis, drug-induced cholestasis, gallstone disease, and autoimmune cholestatic liver disease. 

Uetrecht, J., Currents trends in drug-induced autoimmunity, Autoimmun., 4, 309, 2005. 

Olsen, N.J., Drug-induced autoimmunity, Best Pract. Res. Clin. Rheum., 18, 677, 2004. 

Druet, P. et al., Autoimmune reactions induced by metals, in Autoimmunity and Toxicology Immune Dysregulation Induced by Drugs and Chemicals, Kammunller, M.E., Blocksma, N., and Seinen, W., Eds., Elsevier, Amsterdam, 1989, 347. 

In the previous examples of drug-induced autoimmunity there is little question that the reactions were immune-mediated. For example, it is easy to demonstrate that the... 

Drugs can cause a wide variety of other autoimmune reactions. One example is myasthenia gravis, which is characterized by muscle weakness and is mediated by antibodies against the acetylcholine receptor at the neuromuscular junction. It has been reported in association with penicillamine [66], gold salts [67], and procainamide [68]. Another form of drug-induced autoimmunity is polymyositis, which is an autoimmune disease... 

There are many hypotheses for the mechanism of drug-induced autoimmunity, but none have been clearly demonstrated. It is unlikely that any one mechanism will explain all drug-induced autoimmunity. Table 26.1 lists some of the drugs most commonly associated with autoimmunity and their spectra of toxicity. There are some similarities but each drug also has its own pattern of toxicity. 

Goldstein, N.S. et al., Minocycline as a cause of drug-induced autoimmune hepatitis. Report of four cases and comparison with autoimmune hepatitis, Amer. J. Clin. Pathol., 114, 591,2000. 

Pichler, W.J., Drug-induced autoimmunity, Cum Opin. Allergy Clin. Immunol., 3, 249,... 

Kretz-Rommel, A., Duncan, S.R., and Rubin, R.L., Autoimmunity caused by disruption of central T cell tolerance. A murine model of drug-induced lupus, J. Clin. Invest., 99,1888, 1997. 

The dog is a species that is frequently used in toxicity studies. However, there are few reports in the open literature on dog studies with respect to chemical- or drug-induced hypersensitivity reactions or autoimmune effects, and those that are available lack consistency. For instance, procainamide has been shown to induce lupus-like symptoms (mainly an increase of ANA) in one study [63], but not in another study with younger dogs [64], Similar discrepancies have been observed for hydralazine-induced effects in dogs [5],... 

Masson, M.J., and Uetrecht, J.P., Tolerance induced by low dose D-penicillamine in the brown Norway rat model of drug-induced autoimmunity is immune-mediated. Chem. Res. Toxicol., 17, 82, 2004. 

Descotes, J., The popliteal lymph node assay A tool for studying the mechanisms of drug-induced autoimmune disorders. Toxicol. Lett., 64-65 Spec No, 101,1992. 

---