Glomerular diseases

Hematuria/red blood cell casts (glomerular disease or bleeding in urinary tract)... 

Glomerular diseases (e.g., anti-glomerular basement membrane disease, focal segmental glomerularsclerosis, IgA nephropathy, hemolytic uremic syndrome, systemic lupus erythematosus, Alport s syndrome, amyloidosis, membranous nephropathy, and Goodpasture s syndrome)... 

Methotrexate Sulfonamides Glomerular disease Gold Nonsteroidal antiinflammatory drugs, cyclooxygenase-2... 

Many glomerular diseases, such as those associated with diabetes mellitus or systemic lupus erythematosus, exhibit renal retention of salt and water. The cause of this sodium retention is not precisely known, but it probably involves disordered regulation of the renal microcirculation and tubular function through release of vasoconstrictors, prostaglandins, cytokines, and other mediators. When edema or hypertension develops in these patients, diuretic therapy can be very effective. If heart failure is also present, see the warnings mentioned above. 

Hunt JS, McGiven AR, Day WA. 1976. Immune complex glomerular disease in argyric mice. Pathology 8 205-210. 

Border WA. Transforming growth factor-P and the pathogenesis of glomerular diseases. Current Opinion in Nephrology and Hypertension 1994, 3, 54—58. 

Familial forms of nephrotic syndrome are very rare, but they are very important for the elucidation of the molecular pathogenesis of proteinuria in the far more common acquired glomerular diseases accompanied by nephrotic syndrome. 

Recent progress in understanding podocyte biology in rare inherited glomerular diseases gives the chance to understand in the near future the molecular pathogenesis of increased glomerular permeability in the much more common acquired forms of nephrotic syndrome. 

Y2. Yang, D. H., Goyal, M., Sharif, K., Kershaw, D., Thomas, P., Dysko, R., and Wiggins, R., Glomerular epithelial protein 1 and podocalysin-like protein 1 in inflammatory glomerular disease (crescentic nephritis) in rabbit and man. Lab. Invest. 74, 571-584 (1996). 

Among the various primary and secondary glomerular diseases, diabetic nephropathy represents the most common cause of stage 5 chronic kidney disease accounting for about 44% of all patients on dialysis. One important mediator of glomerular injury in diabetic... 

Excretion of markedly elevated levels of protein is indicative of glomerular disease, whereas low-level proteinuria indicates tubular damage or very early/lowgrade glomerular injury (Peterson et al. 1969 Finco 1997). Further determination of the severity and... 

Tencer J, Torffvit O, Thysell H et al. (1998) Proteinuria selectivity index based on a2-macroglobulin or IgM is superior to the IgG based index in differentiating glomerular diseases. Kidney Int 54 2098-2105... 

Tencer J, Bakoush O, Torffvit O (2000) Diagnostic and prognostic significance of proteinuria selectivity index in glomerular diseases. Clin Chim Acta 297 73-83 Thongboonkerd V, Klein JB, McLeish KR (2002) Proteomic identification of biomarkers of glomerular diseases. J Am Soc Nephrol 13 120A... 

LAP is also seen in the urine with very early glomerular disease (Bedir et al. 1996). The assay substrate is also a substrate for leukocyte esterase and thus increased neutrophils in the urine (pyuria) will cause a false positive result (Vlaskow et al. 2000). 

Dische FE, Swinson DR, Hamilton EB, Parsons V. Immunopathology of penicUlamine-induced glomerular disease. J Rheumatol 1984 ll(5) 584-5. 

A fatal nephrotic syndrome occurred in a 33-year-old man with renal glomerular disease dependent on pentazocine (SEDA-17, 88). 

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