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Gene targeting

Berger et al. (1998) generated MR knock-out mice by gene targeting. Until day 10 after birth, these mice develop normally. Later they show symptoms of pseudohypoaldosteronism, characterized by massive... [Pg.546]

LRP4 is another receptor of the LDL receptor gene family involved in regulation of embryonic patterning, mainly controlling formation of limb structures. Loss of receptor activity in gene targeted mice or spontaneous mutation in bovine cause abnormal limb development and... [Pg.707]

Kamisugi, Y, Cuming, A.C., and Cove, D.J., Parameters determining the efficiency of gene targeting in the moss PhyscomitreUa patens, Nucl. Acids Res. 33, el73, 2005. [Pg.388]

Briglia M, RIL Eggen, WM de Vos et al. (1996) Rapid and sensitive method for the detection of Mycobacterium chlorophenolicum PCP-1 in soil based on 16S rRNA gene-targeted PCR. Appl Environ Microbiol 62 1478-1480. [Pg.660]

C Welz, W Neuhuber, H Schreier, R Repp, W Rascher, A Fahr. Nuclear gene targeting using negatively charged liposomes. Int J Pharm 196(2) 251-252, 2000. [Pg.287]

Other homeobox gene targeting experiments have resulted in more dramatic developmental defects. Homozygous //ox-1.5 null mutants showed a number of alterations (Chisaka and Capecchi, 1991). The mice died at or shortly after birth, apparently from circulation and/or pulmonary problems. These animals showed hypertrophy of the atria and... [Pg.101]

McMahon In terms of the model you are presenting that H19 might have a functional role, what has been done with regard to gene targeting to remove the H19 transcriptional locus or to ectopically express it in transgenics ... [Pg.32]

Malek A, Czubayko F, Aigner A (2008) PEG grafting of polyethylenimine (PEI) exerts different effects on DNA transfection and siRNA-induced gene targeting efficacy. J Drug Target 16 124-139... [Pg.22]

Xie, W., Stribley, J., Chatonnet, A. et al. Postnatal development delay and supersensitivity to organophosphate in gene targeted mice lacking acetylcholinesterase. /. Pharmacol. Exp. Then 293 896-902, 2000. [Pg.208]


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Cardiovascular system gene therapy targets

Cellular retinoic acid binding proteins gene targeting

Conditional gene targeting

Disease targets for gene therapy

Drug Targets and Toxicological Profiles by Gene Expression Analysis

Drug target genes

Embryonic stem cell gene targeting

Endogenous target genes

Eukaryotic gene targeting

Gene Targeting and Genome Editing

Gene brain targeting

Gene delivery targeted

Gene delivery targeting

Gene disruption/knockout, targeted

Gene nuclear targeting

Gene products targeting small molecules

Gene pulmonary delivery/targeting

Gene targeting replacement vector

Gene targeting technology

Gene therapy liver targeting

Gene therapy targets. Table

Gene-targeting applications

Generation of Genetically Modified Mice by Gene Targeting

Genes targeted disruption

Genome-wide Computational Screen for Candidate HIF Target Genes in Drosophila melanogaster and Caenorhabditis elegans

HIF target genes

Herpes simplex virus type 1 thymidine kinase a target for gene-therapy based anticancer drugs

Homeobox genes targeted

Kidney specific gene targeting

MicroRNA target genes

Newer pharmacologic approaches targeting receptors and genes

PPARa target genes

Peroxisome proliferator-activated receptor target gene identification

Polymerase chain reaction target genes

Potential Disease Targets for Gene Therapy

Retinoid receptors gene targeting

Screen for candidate HIF target genes

Sickle cell anemia, gene targeting

Somatic gene therapy cell targetting

Target Genes of the NR4A Subfamily

Target gene expression

Target genes transcription

Target identification, drug discovery genes

Targeted gene delivery vectors

Targeted gene delivery vectors carriers

Targeted gene delivery vectors chitosan

Targeted gene replacement

Transgenic animals embryonic stem cell gene targeting

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