Conditional gene targeting

Clausen, B.E., Burkhardt, C., Reith, W., Renkawitz, R., and Forster, I. (1999) Conditional Gene Targeting in Macrophages and Granulocytes using LysMcre Mice. Transgenic Research 8, 265-277. 

Conditional Gene Targeting vectors of the type described above induce null alle-... 

Torres RM, Kuhn R (1997), Laboratory protocols for conditional gene targeting, In Torres RM, Kuhn R (Eds), Oxford University Press, Oxford, pp. 1-167. 

Some of the LP kinase and lyase mutant mice have also been reported and their phenotypes are consistent with receptor mutant mice (Escalante-Alcalde et al., 2003 Schmahl et al., 2007). However, a number of enzymes are involved in lipid metabolic pathways so the existence of functional redundancy is therefore conceivable. Ongoing multiple and conditional gene targeting studies are helping to elucidate these pathways. 

Haviv YS, Curiel DT. Conditional gene targeting for cancer gene therapy. Adv Drug Deliv Rev 2001 53 135-154. 

D.E. Gutstein, G.E. Morley, G.I. Fishman, Conditional gene targeting of connexin43 exploring the consequences of gap junction remodeling in the heart. Cell Commun Adhes 8 (2001) 345-348. 

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