Targeted gene delivery vectors

Segura and group prepared protein-targeted cationic polymers by ATRP using the grafting from approach. The application of grafting from and grafting to approaches to prepare biomolecular chimeras by LRP has 

---

Gordon EM, Levy JP, Reed RA, etal. Targetingmetastaticcancerfrom the inside Anew generation of targeted gene delivery vectors enables personalized cancer vaccination in situ. Int J Oncol 2008 33 665-675. 

Hallenback PL, Stevenson SC. Targetable Gene Delivery Vectors. In Habib NA, ed. Cancer Gene Therapy Past Achievements and Future Challenges. New York Kluwer Academic/Plenum, 2000 37-46. 

Boeckle S, Wagner E (2006) Optimizing targeted gene delivery chemical modification of viral vectors and synthesis of artificial virus vector systems. AAPS J 8 E731-E742... 

FIGURE 13.6 Viral-nonviral hybrid vectors. DNA is bound to a poly-L-lysine (PLL)-trans-ferrin conjugate (A) to form a PLL-transferrin-DNA complex (B). Transferrin binds to specific receptors on the surface of some cancer cells, thereby targeting gene delivery to these cells (C). 

Mata M, Glorioso JC, Fink DJ. Targeted gene delivery to the nervous system using herpes simplex virus vectors. Physiol Behav. 2002 77 483-488. 

Lotze MT, Kost TA (2002) Viruses as gene delivery vectors application to gene function, target validation, and assay development. Cancer Gene Ther 9(8) 692-699... 

Schaffer DV, Lauffenburger DA (2000) Targeted synthetic gene delivery vectors. Curr Opin Mol Ther 2 155-161... 

Douglas, J. T., Rogers, B. E., Rosenfeld, M. E., et al. Targeted gene delivery by tro-pism-modified adenoviral vectors. Nature Biotechnol. 14 1574-1578, 1996. 

Morizono K, Chen IS (2005), Targeted gene delivery by intravenous injection of retroviral vectors, Cell Cycle 4 231-237. 

Figure 7.1-3. The ideal synthetic (nonviral) gene delivery vector. After dense DNA packaging is accomplished (e.g., by protamine sulfate), the surface of synthetic particles (which is usually positively charged) needs to be shielded (e.g., by poly (ethylene-glycol) [PEG]) so that they do not attach to blood elements or to each other and, therefore, have an extended circulating plasma half-life (1) (passive targeting to leaky vessels ). The surface of the particles will contain specific ligands for active targeting to selected cells/ tissues (2). By engineering viral fusion proteins to the particle coat, cell entry is facilitated...

Henning P, Andersson K M, Frykholm K, et al. (2005). Tumor cell targeted gene delivery by adenovirus 5 vectors carrying knobless fibers with antibody-binding domains. Gene Ther. 12 211-224. 

---