Target genes transcription

Adenomatosis Polyposis Coli (APC). Whereas Dvl is a Wnt pathway activator, GSK3, Axin and APC are all inhibitors. Axin and APC help to stabilize the activity of GSK3, keeping (3-catenin levels low and Wnt target gene transcription off in the absence of a Wnt signal (Fig. 2a). 

Bagchi, M.K., Tsai, S.Y., Tsai, M.J., O Malley, B.W. (1991). Progesterone enhances target gene transcription by receptor free of heat shock proteins hsp90, hsp56, and hsp70. Mol. Cell. Biol. 11. 4998-5004. 

PEPTIDE NUCLEIC ACIDS (PNA) BINDING-MEDIATED TARGET GENE TRANSCRIPTION 67... 

CORRELATION BETWEEN PNA BINDING GENERATED D-LOOPS AND NATURAL PROMOTER IN TARGET GENE TRANSCRIPTION... 

Heterodimeric RAR-RXR complexes bind to and regulate target gene transcription from DR1-, DR2-, and DR5-type response elements (see previous sections). Thus, it is conceivable that retinoids could be developed that would selectively activate a RAR RXR complex bound to a DR5 RARE, for example, but not the same complex bound to either DRl or DR2 RAREs, or other, unknown response elements. It has been suggested that such a phenomenon may be caused by the existence of alternative conformations of the RAR-RXR heterodimeric complexes bound to these dif-... 

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