MicroRNA target genes

Kiriakidou M, Nelson PT, Kouranov A, Fitziev P, Bouyioukos C, Mourelatos Z, Hatzigeorgiou A 2004. A combined computational-experimental approach predicts human microRNA targets. Genes Dev 18(10) 1165-1178. 

Doeneh JG, Sharp PA. Speeificity of microRNA target selection in translational repression. Genes Dev 2004 18 504-511. 

Lewis, B.P. Burge, C.B. Bartel, D.P. Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets. Cell 2005,120 (1), 15-20. 

Lewis BP, Burge CB, Bartel DP 2005. Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets. Cell 120(l) 15-20. Meltzer PS 2005. Cancer genomics small RNAs with big impacts. Nature 435 745-746. Cheng AM, Byrom MW, Shelton J, Ford LP 2005. Antisense inhibition of human miRNAs and indications for an involvement of miRNA in cell growth and apoptosis. Nucleic Acids Res 33(4) 1290-1297. 

Figure 13.4 Genomic visualization produced by the UCSC genome browser by the rtracklayer example. The track named targetTrack showing microRNA target sites for the differentially expressed genes in the human stem cell experiment, was uploaded to the browser from R. We find, for example, that there is a SNP within the target site.

The hsTargets data.frame contains columns for the ID, chromosome, start position, end position, and strand (+ or —) for each microRNA target site. In the code below, we subset hsTargets for the genes of interest, which are stored in the variable named ensembllDs ... 

Figure 5.2 Integration of microRNA target pattern as a new layer of regulation of gene expression.

In recent years, it has become evident that microRNAs (miRs) play a significant role in the regulation of plant development [45-51], biotic and abiotic stress response and, in a few cases, central (primary) metabolism [52-58]. Expression of miR target genes could be reduced by overexpressing the corresponding miRs, or ele-... 

Gambari R, Fabbri E, Borgatti M et al (2011) Targeting microRNAs involved in human diseases a novel approach for modification of gene expression and drug development. Biochem Pharmacol 82 1416-1429... 

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