Cardiovascular system gene therapy targets

While the initial studies in gene-targeted mice suggest that PAR in the CNS may play an important role in memory function, further studies are required to better understand the role of central PAR and their potential role as therpeutic targets. However, due to the prominent role of p, Ak and P2AR in the cardiovascular system, it may be difficult to identify ligands for CNS therapies which lack significant side effects. 

---