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Metastasis gastric

Amhiru S, Miyazaki M, Ito H et al (2001) Benefits and limits of hepatic resection for gastric metastasis. Am J Surg 181 279-283... [Pg.134]

Mashino K, Sadanaga N, Yamaguchi H, et al. Expression of chemokine receptor CCR7 is associated with lymph node metastasis of gastric carcinoma. Cancer Res 2002 62 2937-2941. [Pg.347]

Roder JD, Bottcher K, Busch R, Wittekind C, Hermanek P, Siewert JR. Classification of regional lymph node metastasis from gastric carcinoma. German Gastric Cancer Study Group. Cancer 1998 82(4) 621-631. [Pg.233]

The 5-yr survival rate after curative resection for gastric cancer is only 30-40%. Treatment failure in these cases stems from a combination of local or regional recurrence and distant metastasis. This has stimulated interest in adjuvant and postoperative therapy in the hope of improving treatment results. [Pg.257]

Cadherins. Cadherins are a group of glycoproteins that facilitate Ca2+-dependent cell-cell adhesive interactions.20 When cadherin function is disrupted, the release of a tumor cell can result. It was shown that the aggressive metastasis of undifferentiated epithelial carcinoma cells that had lost cell-cell adhesion could be stopped by transfection with E-cad-herin cDNA.21 Therefore, it was suggested that E-cadherin suppresses metastasis,22 which was further supported by more recent studies that showed the loss of adhesion of human gastric, prostatic, and lung cancer cells was due to the gene mutation of a protein associated with the proper function of cadherin.23... [Pg.380]

Plebani M, Herszenyi L, Carraro P, De PM, Roveroni G, Cardin R, et al. Urokinase-type plasminogen activator receptor in gastric cancer Tissue expression and prognostic role. Clin Exp Metastasis 1997 15(4) 418-425. [Pg.101]

M. (1998). Establishment of lymph node metastatic model for human gastric cancer in nude mice and analysis of factors associated with metastasis. Clin. Exptl. Metastasis 16, 389-398. [Pg.291]

MMPs also act as predictors of recurrence or metastatic risk. High preoperative serum levels of MMP-2 or MMP-3 are predictive of recurrence in patients with advanced urotheliai carcinoma. Furthermore, high levels of MMP-2 in ovarian tumor cells can predict tumor recurrence. The expression of certain MMPs is predictive of metastatic risk. For example, expression of MMP-1 is associated with lymph node metastasis in cervical and peritoneal metastasis in gastric cancer. MMP inhibition may be a therapeutic strategy for cancer. ... [Pg.763]

Overexpression of Ll-cadherin in gastric cancer is associated with lymph node metastasis. Biochemical and Biophysical Research Communications,... [Pg.273]

CCR7 expression was positively correlated with regional LN metastasis in T1 breast cancer [21], cervical cancer [22], melanoma [23], colorectal carcinoma [24], gastric carcinoma [25, 26], oral and oropharyngeal squamous cell carcinoma [27], squamous cell carcinoma of tonsil [28], esophageal squamous cell carcinoma [29], squamous cell carcinoma of the head and neck (SCCHN) [30], thyroid carcinoma [31], nonsmall cell lung cancer [32], hepatocellular cancer [33], prostate cancer [34], adult T-cell leukemia [35], and chronic lymphocytic leukemia [36, 37]. [Pg.96]

Fukui, R., H. Nishimori, F. Hata, T. Yasoshima, K. Ohno, H. Nomura, Y. Yanai, H. Tanaka, K. Kamiguchi, R. Denno, N. Sato, and K. Hirata. 2005. Metastases-related genes in the classification of liver and peritoneal metastasis in human gastric cancer. J Surg Res 129 94. [Pg.129]

The cadherin family of glycoproteins mediates calcium- dependent cell-cell adhesion. Cadherins frorm intercellular complexes binding cells together (Fig. 18.12A). They are anchored intracellularly by catenins, which bind to actin filaments. Loss of E-cadherin expression may contribute to the ability of cancer cells to detach and migrate in metastasis. Individuals who inherit a mutation in E cadherin (this mutation is designated as CDHl) are sharply predisposed to developing diffuse type gastric cancer. [Pg.328]

NIS expression might, in the future, be used in the diagnosis of gastric cancer metastasis or the absence of NIS expression as a sign of malignancy in gastric lesions. [Pg.220]

Y7. Yoshikawa, T., Tissue inhibitor of matrix metalloproteinase-1 in the plasma of patients with gastric carcinoma. A possible marker for serosal invasion and metastasis. Cancer 86, 1929-1935 (1999). [Pg.85]

M2. Marutsuka, T., Shimada, S., Shiomori, K., Hayashi, N., Yagi, Y., Yamane, T., et al.. Mechanisms of peritoneal metastasis after operation for non-serosa-invasive gastric carcinoma An ultrarapid detection system for intraperitoneal free cancer cells and a prophylactic strategy for peritoneal metastasis. Clin. Cancer Res. 9, 678-685 (2003). [Pg.106]

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