Cancer hepatocellular

Despite the large number of molecules found to interact with the TGF- 3 pathway, few have been identified as functional tumor suppressors using either mouse or human genetics. The TGF-beta pathway is inactivated in nearly all gastrointestinal cancers, from TBRII, TBRI, Smad 2, and Smad 4. Recent exciting data have revealed the role of ELF, a key TGF- 3 pathway adaptor, in hepatocellular cancer suppression. 

Data on phase 1 trial in 34 patients with imresectable hepatocellular cancer were presented at the 41st ASCO meeting. May 2005. Patients received 750-1250 mg Vatalanib orally, once daily in a 28-day cycle. The most common... 

Shachaf CM, Kopehnan AM, Arvanitis C et al (2004) MYC inactivation uncovers pluripotent differentiation and tumour dormancy in hepatocellular cancer. Nature 431 1112-1117... 

Capecitabine Inhibits TS incorporation of FUTP into RNA resulting in alteration in RNA processing incorporation of FdUTP into DNA resulting in inhibition of DNA synthesis and function Breast cancer, colorectal cancer, gastroesophageal cancer, hepatocellular cancer, pancreatic cancer Diarrhea, hand-foot syndrome, myelosuppression, nausea and vomiting... 

M. A. Adson, Primary hepatocellular cancers—Western experience, Survey of the Liver and Biliary Tract (L. H. Blumgart, ed.), Churchill Livingstone Publisher, New York, 1988, pp. 1153-1165. 

Enwonwu, C.O. The role of dietary aflatoxin in the genesis of hepatocellular cancer in developing countries. Lancet 1984/11 956—958... 

Curley, S.A., Bomalaski, J.S., Ensor, C.M., Holtsberg, F.W., Clark, M.A. Regression of hepatocellular cancer in a patient treated with arginine deiminase (case report). Hepato-Gastroenterol. 2003 50 1214-1216... 

Studies in rats found a significant increase in hepatocellular cancer at doses higher than that administered to humans. 

W9. Warnoek, M. L., and Reisman, R., Variant alkaline phosphatase in human hepatocellular cancers. Clin. Chim. Acta 24, 5-11 (1969). 

Hopfner, M., Schuppan, D. et al. (2008). Growth factor receptors and related signalling pathways as targets for novel treatment strategies of hepatocellular cancer. World J Gastroenterol 14(1) 1-14. 

CCR7 expression was positively correlated with regional LN metastasis in T1 breast cancer [21], cervical cancer [22], melanoma [23], colorectal carcinoma [24], gastric carcinoma [25, 26], oral and oropharyngeal squamous cell carcinoma [27], squamous cell carcinoma of tonsil [28], esophageal squamous cell carcinoma [29], squamous cell carcinoma of the head and neck (SCCHN) [30], thyroid carcinoma [31], nonsmall cell lung cancer [32], hepatocellular cancer [33], prostate cancer [34], adult T-cell leukemia [35], and chronic lymphocytic leukemia [36, 37]. 

Schimanski, C. C., R. Bahre, I. Gockel, T. Junginger, N. Simiantonaki, S. Biesterfeld, T. Achenbach, T. Wehler, P. R. Galle, and M. Moehler. 2006. Chemokine receptor CCR7 enhances intrahepatic and lymphatic dissemination of human hepatocellular cancer. Oncol Rep 16 109-113. 

Austin et al (65) performed a case-control study using 80 hepatocellular cancer patients and 146 matched hospital controls. Relative risks for exposures to herbicides and other pesticides were 1.0 and 2.1 (95% Cl 0.6-6.9), respectively. 

As with many polymorphisms, epidemiology studies have been done to explore risks to diseases in the absence of information about etiology, substrates, etc. Some of the reports include suggestion of more hepatocellular cancer in PMs " and lack of association of leukemia with polymor-phism505. Other possible relationships have been explored but evidence for any associations is limited at this time . ... 

The principal side effects of the 17a-alkylated androgens are hepatic, including cholestasis, and uncommonly, peliosis hepatis (blood-filled hepatic cysts). Hepatocellular cancer has rarely been reported. When administered at high doses, these androgens are more likely than others to affect serum lipid concentrations, specifically to decrease high-density lipoprotein cholesterol and increase low-density lipoprotein cholesterol. 

Wu Y, Cahill PA, Sitzmann JV (1996) Decreased angiotensin II receptors mediate decreased vascular response in hepatocellular cancer. Ann Surg 223 225-231... 

Hepatocellular cancer (HCC) is a common cause of cancer death worldwide with a striking geographical variation in incidence. In the People s Republic of China, HCC has an incidence rate of 150 cases per 100,000 per year in some regions and accounts for over 250,000 deaths annually. Major etiological factors associated with development of HCC include iufection with hepatitis B or C viruses and exposure to dietaryaflatoxin Bi (AFBi) [26 27]. 

The development of microcatheters with 0.027 endholes (Renegade Hi-Flo, Boston Scientific, and Mass Transit, Cordis) enabled easier delivery of particulates for embolization of hepatocellular cancer and uterine fibroids. Unfortunately, the 0.016 pusher wires will become trapped between the 0.018 microcoil and the inner diameter of these larger lumen microcatheters. If coil delivery is desirable using a pusher wire, a Teflon coated standard 0.021 wire is utilized. Our preference though is to deliver... 

Takamori R et al. (2000) Needle-tract implantation from hepatocellular cancer is needle biopsy of the liver always necessary Liver Transpl 6 67-72... 

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