Gastric cancer, humans

We have linked the gastric cancer model of Sugimura to the examination of the occurrence of human gastric cancer and to consideration of the underlying mechanisms ... 

Lan-Kai-Wei etal. (1991). The clinical and laboratory studies of superoxide dismutase activity in the human whole blood with early gastric cancer. Free Rad. Res. Commun. 12-13, 759-760. 

Prolonged hypergastrinemia leading to the development of colonic polyps and potentially adenocarcinoma in rats was a concern that has proven to be unfounded with long-term use in humans.19 The FDA has stated that there is insufficient evidence linking PPI use to atrophic gastritis, intestinal metaplasia, or gastric cancer.20... 

Shao, X.D., Wu, K.C., Hao, Z.M., Hong, L., Zhang, J. and Fan, D.M. (2005) The potent inhibitory effects of cisapride, a specific blocker for human efher-a-go-go-related gene (HERG) channel, on gastric cancer cells. Cancer Biology e[ Therapy, 4, 295-301. 

However, high levels of certain protease inhibitors correlate positively with enhanced metastatic potential. For example, high levels of the PA inhibitor, PAI-1, correlate directly with poor prognosis in human breast and gastric cancers (J2, Nl) and indeed correlate with uPA itself (Rl). 

Kasprzyk, P. G., S. U. Song, P. P. Di Fiore, and C. R. King. Therapy of an animal model of human gastric cancer using a combination of anti-erbB-2 monoclonal antibodies. Cancer Res, 52 2771-2776.1992. 

Jiang W, Kahn SM, Guillem JG, Lu SH, Weinstein IB (1989) Rapid detection of ras oncogenes in human tumors applications to colon, esophageal, and gastric cancer. Oncogene 4 923-928... 

The second example of the use of the intermittent heating is for identifying centromeres in gastric cancer cells (Kitayama et al., 1999). A panel of 17 centromeric specific a-satellite probes was used for detecting chromosomal instability in these cells. The study of centromeres is important because chromosomal abnormalities are a well-known characteristic of human cancers. 

Quercetin has been shown to inhibit the growth of several human and animal cancer cell lines in vitro. However, the sensitivity of different cell lines varies considerably. In human breast cancer cells the IC50 of quercetin for inhibition of growth was 23 xM (7 pg/ml), whereas in human gastric cancer cells the IC50 was 32 to 55 M. A head and neck squamous cell carcinoma line is unaffected by quercetin at <110 M. Because growth inhibition of sensitive cells results from arrest of cell-cycle progression at the Gj-S boundary, this effect of quercetin is likely to be independent of its inhibition of topoisomerase II. 

Fukushige, S., Matsubara, K., Yoshida, M., Sasaki, M., Suzuki, T., Semba, K., Toyoshima, K., and Yamamoto, T. (1986). Localization of a novel v-erbB-related gene, c-erbB-2, on human chromosome 17 and its amplification in a gastric cancer cell line. Mol. CM Biol. 6, 955-958. 

On the other hand, a given K+ channel may well express in multiple cancer cells of distinct histological origins therefore even a relatively specific K+ channel blocker might inhibit proliferation of several distinct cells. For instance, cisapride can inhibit proliferation of breast cancer cells, neuroblastoma cells, gastric cancer cells, etc., simply because HERG is ubiquitously expressed in human tissues. 

Liu SI, Chi CW, Lui WY, Mok KT, Wu CW, Wu SN (1998) Correlation of hepato-cyte growth factorinduced proliferation and calcium-activated potassium current in human gastric cancer cells. Biochim Biophys Acta 1368 256-266... 

Molecular risk biomarkers could detect systemic or local changes indicating that the carrier of this specific biomarker is at higher risk for disease development in the future. Examples include the presence of human papillomavirus in the cervix, which is associated with a higher risk for the development of cervical cancer, the association between Hdicohacterpylori and gastric cancer as well as EBV and nasopharyngeal carcinoma. The drawback of these markers is that they are not helpful for the detection of early disease. 

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