Metastasis, suppression

Bandyopadhyay, S. et al. (2006) Interaction of KAIl on tumor cells with DARC on vascular endothelium leads to metastasis suppression. Nature Medicine, 12, 933-938. 

Goldberg SF, Miele ME, Hatta N, Takata M, Paquette-Straub C, Freedman LP, Welch DR. 2003. Melanoma metastasis suppression by chromosome 6 Evidence for a pathway regulated by CRSP3 and TXNIP. Cancer Res 63 432-440. 

McKallip RJ, Nagarkatti M, Nagarkatti PS. Delta-9-tetrahydrocannabinol enhances breast cancer growth and metastasis by suppression of the antitumor immune response. J Immunol 2005 174 3281-9. 

Abnormal growth factor signaling pathways lead to increased cell proliferation, suppression of apoptotic signals, and invasion contributing to metastasis. 

Shibata, M.A., J. Morimoto, and Y. Otsuki, Suppression of murine mammary carcinoma growth and metastasis by HSVtk/GCV gene therapy using in vivo electroporation. Cancer Gene Ther, 2002. 9(1) 16-27. 

Miura D, Miura Y, Yagasaki K. 2004. Resveratrol inhibits hepatoma cell invasion by suppressing gene expression of hepatocyte growth factor via its reactive oxygen species-scavenging property. Clin Exp Metastasis 21 445 451. 

Aggarwal BB, Shishodia S, Takada Y, Banerjee S, Newman RA, Bueso-Ramos CE, Price JE. 2005. Curcumin suppresses the paclitaxel-induced nuclear factor-kappaB pathway in breast cancer cells and inhibits lung metastasis of human breast cancer in nude mice. Clin Cancer Res 11 7490-7498. 

Yamamoto, H., Irie, A., Fukushima, Y., Ohnishi, T., Arita, N., Hayakawa, T. and Sekiguchi, K. (1996) Abrogation of lung metastasis of human fibrosarcoma cells by ribozymemediated suppression of integrin alpha6 subunit expression. Int. J. Cancer, 65, 519-524. 

Cadherins. Cadherins are a group of glycoproteins that facilitate Ca2+-dependent cell-cell adhesive interactions.20 When cadherin function is disrupted, the release of a tumor cell can result. It was shown that the aggressive metastasis of undifferentiated epithelial carcinoma cells that had lost cell-cell adhesion could be stopped by transfection with E-cad-herin cDNA.21 Therefore, it was suggested that E-cadherin suppresses metastasis,22 which was further supported by more recent studies that showed the loss of adhesion of human gastric, prostatic, and lung cancer cells was due to the gene mutation of a protein associated with the proper function of cadherin.23... 

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