GABA-A receptors subunits

Molher H., Malherbe P., Draguhn A. et al. (1990). GABA-A-receptor subunits ... 

Smith MJ, Beck M, Stephenson FA. 2003. Can the yeast two-hybrid system be used to study assembly domains of GABA-A receptor subunits British Neurosci Assoc Abstr 17 26.12. 

Wafford KA, Burnett D, Harris RA, Whiting PJ GABA A receptor subunit expression and sensitivity to ethanol, in Advances in Biomedical Alcoholism Research. Edited by Taberner PV, Badawy AA. Oxford, England, Pergamon, 1993, pp 327-330... 

Brussaard, A. B., Kits, K. S., Baker, R. E., Willems, W. R, Leyting-Vermeulen, J. W., Voorn, R, Smit, A. B., Bicknell, R.J., and Herbison, A. E. (1997). Plasticity in fast synaptic inhibition of adult oxytocin neurons caused by switch in GABA(A) receptor subunit expression. Neuron 19, 1103-1114. 

Glykys, J., Mann, E. O., and Mody, I. (2008). Which GABA(A) receptor subunits are necessary for tonic inhibition in the hippocampus J. Neurosci. 28, 1421-1426. 

Lovick, T. A., Griffiths, J. L., Dunn, S. M., and Martin, I. L. (2005). Changes in GABA(A) receptor subunit expression in the midbrain during the oestrous cycle in Wistar rats. Neuroscience 131,... 

Rieff HI, Raetzman LT, Sapp DW, Yeh HH, Siegel RE, et al. 1999. Neuregulin induces GABA(A) receptor subunit expression and neurite outgrowth in cerebellar granule cells. J Neurosci 19 10757-10766. 

Fritschy JM, Weinmann O, Wenzel A, Benke D (1998) Synapse-specific localization of NMDA and GABA(A) receptor subunits revealed by antigen-retrieval immunohistochemistry. J Comp Neurol 590 194-210. 

Carlson BX, Elster L, Schousboe A (1998) Pharmacological and functional implications of developmentally-regulated changes in GABA(A) receptor subunit expression in the cerebellum. Eur J Pharmacol 352 1-14. 

Bailey ME, Matthews DA, Riley BP, Albrecht BE, Kostrzewa M, Hicks AA, Harris R, Muller U, Darhson MG, Johnson KJ (1999) Genomic mapping and evolution of human GABA(A) receptor subunit gene clusters. Mamm Genome 10 839-843. 

McCauley JL, Olson LM, Delahanty R, Amin T, Nurmi EL, Organ EL, Jacobs MM, Folstein SE, Haines JL, Sutcliffe JS (2004) A linkage disequilibrium map of the 1-Mb 15ql2 GABA(A) receptor subunit cluster and association to autism. Am J Med Genet. 

Brooks-Kayal, AR, Shumate, MD, Jin, H, Rikhter, TY, Coulter, DA (1998) Selective changes in single cell GABA(A) receptor subunit expression and function in temporal lobe epilepsy. Nat Med, 4 1166-1172. 

Edenberg HJ, Dick DM, Xuei X, et al Variations in GABRA2, encoding the alpha 2 subunit of the GABA(A) receptor, are associated with alcohol dependence and with brain oscillations. Am J Hum Genet 74 705-714, 2004... 

Hood HM, Buck KJ. Allelic variation in the GABA-A receptor yl subunit is associated with genetic susceptibility to ethanol-induced motor incoordination and hypothermia, conditioned taste aversion, and withdrawal in BxD/Ty recombinant inbred mice. Alcohol Clin Exp Res 2000 24 1327-1334. 

Hansen, S. L Ebert, B., Fjalland, B., and Kristiansen, U. (2001) Effects of GABA(A) receptor partial agonists in primary cultures of cerebellar granule neurons and cerebral cortical neurons reflect different receptor subunit compositions. Br. J. Pharmacol. 133, 539-549. 

Structure and localization of the gene encoding the human GABA-A receptor pi subunit (GABRP)." ... 

Waeber C, Hoyer D, Palacios JM S-HTj receptors in the human brain audioradiographic visualization. Neuroscience 31 393-400, 1989 Wafford KA Ethanol sensitivity of the GABA A receptor expressed in Xenopus oocytes requires 8 amino acids contained in the gamma2L subunit. Neuron 7 27-33, 1991... 

The GABA-A receptor (Fig. 4.4) constitutes an example of an ionotropic receptor. It is composed of five different protein subunits two alpha-1, two beta-2 and one gamma-2 and is therefore called a pentamer. The benzodiazepine binding site is located at the al/y2 interphase, whereas the activation sites for GABA are located at the al/p2 inteiphase. Once a benzodiazepine molecule has bound, the receptor will change its shape so that it responds more to GABA. Upon activation of the GABA-A receptor the ion channel opens and chloride ions can pass. 

Figure 4.4 View from above onto a GABA-A receptor. The GABA-A receptor is composed of five subunits, i.e. two a. two 02 and one, 2 subunits. Following activation of the receptor, the chloride ions will enter the cell through the channel formed by the pentamer...

Kralic JE et al GABA(A) receptor alpha-1 subunit deletion alters receptor subtype assembly, pharmacological and behavioral responses to benzodiazepines and zolpidem. Neuropharmacology 2002 43 685. [PMID 12367614]... 

Glykys,J., and Mody, I. (2006). Hippocampal network hyperactivity after selective reduction of tonic inhibition in GABA A receptor alpha5 subunit-deficient mice. J. Neurophysiol. 95, 2796-2807. 

Smith, S. S., Gong, Q. H., Hsu, F. C., Markowitz, R. S., ffrench-Mullen, J. M., and Li, X. (1998a). GABA(A) receptor alpha4 subunit suppression prevents withdrawal properties of an endogenous steroid. Nature 392, 926—930. 

Wei, W., Zhang, N., Peng, Z., Houser, C. R., and Mody, I. (2003). Perisynaptic localization of delta subunit-containing GABA(A) receptors and their activation by GABA spillover in the mouse dentate gyrus. J. Neurosci. 23, 10650-10661. 

Wohlfarth, K. M., Bianchi, M. T., and Macdonald, R. L. (2002). Enhanced neurosteroid potentiation of ternary GABA(A) receptors containing the delta subunit. J. Neurosci. 22, 1541-1549. 

---