Dentate gyrus

A Short-term group B Long-term group 

In order to confirm the increased postischemic cell proliferation with an independent marker, we stained monkey brain sections for Ki67 (Kee et al. 2002). Ki67 immunohistochemistry confirmed that proliferation was increased on day 9 (Fig. 9B) as compared to control (Fig. 9A), and subsequently declined (Fig. 9C). The Ki67+ cells were frequently grouped similarly to the BrdU+ cells, in clusters or doublets (Fig. 9D, E). Double-labeling for BrdU and Ki67 demonstrated they stain the same cells (Fig. 9F). BrdU also colabeled with the mitotic marker phosphohistone H3 (Fig. 9G). 

Control Ischemia Control Ischemia Control Ischemia Control Ischemia 

not available p 0.05 versus control (day 9 sham operation) p 0.05 versus postis-chemic day 9 Kruskal-Wallis or Mann-Whitney tests 

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Berger O, Li G, Han SM, Paredes M, Pleasure SJ (2007) Expression of SDF-1 and CXCR4 during reorganization of the postnatal dentate gyrus. Dev Neurosci 29 48-58... 

Lu M, Grove EA, MiUer R1 (2002) Abnormal development of the hippocampal dentate gyrus in mice lacking the CXCR4 chemokine receptor. Proc Natl Acad Sci USA 99 7090-7095 Luster AD (1998) Chemokines-chemotactic cytokines that mediate inflammation. N Engl 1 Med 338 436 45... 

In that and subsequent studies (Kosofsky 1985 Blue et al. 1988a), a distinct laminar pattern of innervation was found in somatosensory cortex, and a quite different pattern in the cingulate cortex, hippocampus, and dentate gyrus, where there are distinct bands of highly varicose axons. In the primate, the 5-HT innervation of cerebral cortex is denser and more highly differentiated among different architectonic and functional areas (Kosofsky et al. 1984 Morrison et al. 1982 Morrison and Foote 1986 Wilson and Molliver 1986 Wilson et al. 1989). For example, marked differences in the density and distribution of 5-HT axons are found in the macaque on either side of the central sulcus, in primary motor and somatosensory cortex while... 

Stanton, P. K. Sarvey, J. M. (1987). Norepinephrine regulates long-term potentiation of both the population spike and dendritic EPSP in hippocampal dentate gyrus. Brain Res. Bull. 18, 11519. 

Cell counts were performed in the hippocampal dentate gyrus at three levels along the dor-soventral axis in all the animals. BrdU-positive... 

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