Motor incoordination

In the search for new structures with antiinflammatory activities some 1-substituted 3-dimethylaminoalkoxy-lJ/-indazoles (704) have been synthesized and pharmacologically tested (66JMC38). Doses of 20-40 mg g i.p. produced sedation, muscle relaxation and motor incoordination, whereas doses of 80-100 mg kg produced depression. Toxicity was fairly constant in all series, varying from 120 to 150 mg kg i.p., with the exception of compounds possessing a nitro group or an amino group in the indazole nucleus, which provoked cyanosis. 

Hood HM, Buck KJ. Allelic variation in the GABA-A receptor yl subunit is associated with genetic susceptibility to ethanol-induced motor incoordination and hypothermia, conditioned taste aversion, and withdrawal in BxD/Ty recombinant inbred mice. Alcohol Clin Exp Res 2000 24 1327-1334. 

Residues of 2000 to 5000 pg/kg hai r or >10,000 pg/kg brain associated with motor incoordination and decreased swimming ability no observable effect at <2000 pg/kg hair... 

Physical effects of Rohypnol include gastrointestinal disturbances (an upset stomach), slurred speech, decreased blood pressure, muscle relaxation, motor incoordination, and urinary retention (inability to urinate). 

The acute effects of depressants can include euphoria, anxiety reduction, anticonvulsant activity, sedation, ataxia, motor incoordination, impaired judgment, anesthesia, coma, and respiratory depression resulting in death. The benzodiazepines are rarely involved in lethality, but all CNS depressants enhance the effects of other depressant drugs. The physiological effects of high-dose depressants include miosis, shallow respiration, and reduction in reflex responses. 

CNS Barbiturates produce depression of central nervous system in dose dependent manner. In small dose, barbiturates relieve anxiety and are generally used as sedative. In hypnotic dose, it produces sleep resembling normal physiological sleep. Hypnotic dose of barbiturates produce motor incoordination. 

Behavioral and Pharmacological Tests. Behavioral and pharmacological tests involve the observation of clinical signs and behavior. These include signs of changes in awareness, mood, motor activity, central nervous system excitation, posture, motor incoordination, muscle tone, reflexes, and autonomic functions. If these tests so indicate, more specialized tests can be carried out that evaluate spontaneous motor activity, conditioned avoidance responses, operant conditioning, as well as tests for motor incoordination such as the inclined plane or rotarod tests. 

The short-term effects are mainly those of sedation but following longer-term use accumulation may occur, particularly in the case of drugs like diazepam and chlordiazepoxide that have long half-lives due to their active metabolites. After long-term administration (weeks to months) tolerance develops. While most patients rapidly become tolerant to the sedative side effects of these drugs, some patients, particularly the elderly, experience excessive sedation, poor memory and concentration, motor incoordination and muscle weakness. In extreme cases in the elderly, an acute confusional... 

Huntington s disease is an inherited disorder characterized by gradual onset of motor incoordination. The symptoms relate to movement disorders with jerk of the extremities, trunk, face, and neck. The progressive disease causes loss of memory (particularly recognition of friends and family) and is fatal63 This disease is treated only symptomatically. Drugs such as fluoxetine are used to treat depression and irritability. Carbamazepine also is useful in treating associated depression. 

Methysergide (Sansert ) is believed to alter the ability of serotonin to cause inflammation, platelet aggregation (blood clotting), and dilation of blood vessels. However, methysergide has some undesirable side effects, such as motor incoordination and dizziness and can cause heart problems. Usually, the drug is intentionally discontinued for 4-6 weeks twice a year because of these problems. Thus, methysergide is used only in special cases. 

Motor incoordination Presence Motor coordination impaired. Disorganized locomotion (e.g. crossing of paws etc.)... 

In a comparison of astemizole, terfenadine, and tripro-lidine (positive control), only triproUdine caused reduced performance and motor incoordination (64). 

Tetrodotoxin and additional toxic components are found associated with this group. Toxic effects are noted at lOmgkg body weight. Toxic signs include tingling of the oral cavity with salivation, muscle weakness, motor incoordination, skin numbness. 

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