Fresh frozen plasma

Primary blood components iaclude plasma, red blood cells (erythrocytes), white blood cells (leukocytes), platelets (thrombocytes), and stem cells. Plasma consists of water dissolved proteias, ie, fibrinogen, albumins, and globulins coagulation factors and nutrients. The principal plasma-derived blood products are siagle-donor plasma (SDP), produced by sedimentation from whole blood donations fresh frozen plasma (FFP), collected both by apheresis and from whole blood collections cryoprecipitate, produced by cryoprecipitation of FFP albumin, collected through apheresis and coagulation factors, produced by fractionation from FFP and by apheresis (see Fractionation, blood-plasma fractionation). 

Cryoprecipitate Fresh-frozen plasma Autoplex-T VIIFC VIIFvWFAg Fibrinogen Plasminogen Factor XIII all coagulation factors, r VIIFC 11 a, Vila, IXa, Xa DH American Red Cross American Red Cross Hyland, Immuno... 

If administration of this drug is necessary, the nurse monitors the patient s blood pressure and pulse rate every 15 to 30 minutes for 2 hours or more after administration of the heparin antagonist. The nurse immediately reports to the primary health care provider any sudden decrease in blood pressure or increase in the pulse rate The nurse observes the patient for new evidence of bleeding until blood coagulation tests are within normal limits. To replace blood loss, the primary health care provider may order blood transfusions or fresh frozen plasma... 

Fresh frozen plasma Multiple coagulation disorders... 

Prophylactic treatment of Cl INH deficiency consists of Cl INH replacement infusions, androgens (danazol, stanozolol, oxymethalone) or antifibrinolytic agents. Acute treatment employs Cl INH replacement (where available), fresh-frozen plasma, and placement of an airway when significant airway obstruction is evident. Abdominal attacks require IV fluid, analgesics, and watchful waiting . 

Supplement with fresh frozen plasma (15-20 mL/kg) or prothrombin complex concentrate... 

If intracranial hemorrhage is confirmed, administer 5-10 units of cryoprecipitate, evaluate laboratory results, and supplement blood products and platelets as deemed necessary (e.g., 2 units fresh frozen plasma [FFP], 6-8 units platelets)... 

Therapeutic fluids include crystalloid and colloid solutions. The most commonly used crystalloids include normal saline, hypertonic saline, and lactated Ringer s solution. Examples of colloids include albumin, the dextrans, hetastarch, and fresh frozen plasma. 

The primary treatment of recessively inherited coagulation disorders is single-donor fresh-frozen plasma (FFP) that contains all coagulation factors. 

FFP, fresh frozen plasma PCC, prothrombin complex concentrates. 

FFP Fresh-frozen plasma HIV Human immunodeficiency virus... 

Fresh frozen plasma Plasma that is frozen within hours after donation to preserve clotting factors. 

Fresh frozen plasma replaces clotting factors. Although it is often overused, the product is indicated if there is ongoing hemorrhage in patients with a PT or aPTT greater than 1.5 times normal, severe hepatic disease, or other bleeding disorders. 

Williamson LM, Cardigan R (2003) Methylene blue-treated fresh-frozen plasma what is its contribution to blood safety Transfusion. 43 1322-1329. 

Inject subcutaneously or IM when possible. In older children and adults, inject IM in the upper outer quadrant of the buttocks. In infants and young children, the anterolateral aspect of the thigh or the deltoid region is preferred. When IV administration is unavoidable, inject very slowly, not exceeding 1 mg/min. Anticoagulant-induced prothrombin deficiency in adults 2.5 to 10 mg or up to 25 mg (rarely, 50 mg) initially. Determine subsequent doses by prothrombin time (PT) response or clinical condition. If in 6 to 8 hours after parenteral administration (or 12 to 48 hours after oral administration), the PT has not been shortened satisfactorily, repeat dose. If shock or excessive blood loss occurs, transfusion of blood or fresh frozen plasma may be required. 

Management is the same as that outlined above but replacement is with fresh frozen plasma or freeze-dried factor IX concentrate. A wide range of commercial equivalents can be used but are costly. 

Therapy depends, where possible, on correcting the precipitating process. Thereafter, the consumption coagulopathy is reversed by intravenous injection of adequate amounts of cryoprecipitae, fresh frozen plasma and platelets at whatever interval is necessary to achieve measurable plasma levels in parallel with sustained clinical improvements. 

Anticoagulant effect of warfarin maybe reversed by administration of vitamin Kor fresh frozen plasma should only use in situations where INR is severely elevated >10, or when patient is actively bleeding... 

F. Role in therapy Antihemophilic factor concentrates have virtually superceded fresh frozen plasma and cryoprecipi-tate for the treatment of hemophilia A. 

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