Prothrombin complex

Supplement with fresh frozen plasma (15-20 mL/kg) or prothrombin complex concentrate... 

Factor IX Replacement Hemophilia B therapy may include recombinant (produced via transfection of mammalian cells with the human factor IX gene) or plasma-derived (concentrate from pooled plasma) factor IX (see Table 64-2). Guidelines for choosing the factor-concentrate formulation for hemophilia B are similar to the guidelines for hemophilia A. However, older-generation factor IX concentrates containing other vitamin K-dependent proteins (e.g., factors II, VII, and IX), called prothrombin complex concentrates (PCCs), have been associated with thrombogenic side effects. Consequently, these products are not first-line treatment for hemophilia B.11... 

APCC, activated prothrombin complex concentrate PCC, prothrombin complex concentrate vWF, von Willebrand factor. 

Treatment algorithm for the management of patients with hemophilia A and factor VIII antibodies. BU, Bethesda unit PCC, prothrombin complex concentrate a PCC, activated prothrombin complex concentrate. 

FFP, fresh frozen plasma PCC, prothrombin complex concentrates. 

Immediate administration of 100 meg to 1 mg vitamin K subcutaneously or intravenously, followed by administration of FFP as necessary. Vitamin K administration via the intramuscular route may induce hematoma owing to coagulopathy, and intravenous administration should be slow because it has been associated with anaphylaxis. Prothrombin complex concentrate (PCC) at minimum dose of 50 units/kg should be given for life-threatening bleeding.27,28... 

Fig. 2. Generation of tenase and prothrombin complexes. PPL represents the anionic phospholipid surface provided by the platelets (platelet phospholipid). Cleavage of prothrombin by the prothrombinase complex results in the formation of thrombin and the release of a small fragment called prothrombin fragment 1.2 (PFI.2).

Yes Yes Hold warfarin therapy. Give 10 mg slow IV infusion, may repeat dose every 12 h, supplement with plasma or prothrombin complex concentrate (PCC). 

II Prothrombin deficiency 30-40% 3 days Prothrombin complex concentrates (intermediate purity factor IX concentrates)... 

VII Factor VII deficiency 30% 4-6 hours FFP Prothrombin complex concentrates (intermediate... 

There are several possible arrangements tolerating the presence of particles during adsorption of proteins to particulate matrices. Batch adsorption in stirred tanks is performed by contacting adsorbent particles with a cell containing suspension. After protein capture the adsorbent is separated from the broth and the protein of interest can be eluted. This procedure has been described for the isolation of antibiotics [12], the purification of ot-amylase from B. amylo-liquefaciens broth [13], and the isolation of the prothrombin complex from... 

Brummelhuis HGJ (1980) Preparation of the Prothrombin complex. In Curling JM (ed) Methods of plasma protein fractionation. Academic Press, New York, p 117... 

Sultan Y Loyer F In vitro evaluation of factor VI11-bypassing activity of activated prothrombin complex concentrates and factor Vila in the plasma of patients with factor VIII inhibitors thrombin generation test in the presence of collagen-activated platelets. J Lab Clin Med 1993 121 444-452. 

Ariens [432] was the first to describe drug action through indirect mechanisms. Later on, Nagashima et al. [433] introduced the indirect response concept to pharmacokinetic-dynamic modeling with their work on the kinetics of the anticoagulant effect of warfarin, which is controlled by the change in the prothrombin complex synthesis rate. Today, indirect-response modeling finds extensive... 

Prothrombin complex concentrate, cryoprecipitate and fresh frozen plasma, commonly-used coagulation factor products. 

Prothrombin complex is the combination of Factors E, VE, DC, and X. It is indicated for individuals with hemophdia B. In a typical production process, the supernatant resulting from the separation of cryoprecipitate is filtered to remove particles and applied to an anion-exchange column. The coagulation factors are eluted, ultrafiltered, and exposed to 60°C for 10 h for virus inactivation. This is followed by diafiltration, ultrafiltration, and sterile filtration. 

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