Formulations flash-dispersing

Fast-dissolving formulations (flash-dispersing) are not primarily intended to be for buccal delivery the issue here is that they may be taken without water. This causes an important difference in performance relative to ordinary immediate-release products, especially if the drug is in suspension. If the material is swallowed dry, it may adhere to the fundus area, where the amount of shear is low. This causes a significant fraction of the material to be retained resulting in tailing of the absorption phase and an apparently decreased AUC as the material is released over several hours. [Pg.550]

Agricultural Products. Pesticides are frequently applied as emulsifiable concentrates. The active insecticide or herbicide is dissolved in a hydrocarbon solvent which also contains an emulsifier. Hydrocarbon solvent selection is critical for this application. It can seriously impact the efficacy of the formulation. The solvent should have adequate solvency for the pesticide, promote good dispersion when diluted with water, and have a flash point high enough to rniriinii2e flammability hazards. When used in herbicide formulas, low solvent phytotoxicity is important to avoid crop damage. Hydrocarbon solvents used in post-harvest application require special testing to ensure that polycyclic aromatics are absent. [Pg.280]

Chem. Descrip. Polypropoxy quat. ammonium acetate Uses Antislat conditioner for hair rinse preparations emulsifier tor cosmetics and textile flame retardants solvent for phenolic-type germiddes for cosmetics and toiletries antistat for syn. fibers and plastics tabric conditioner lubricant for textile and industrial formulations solvent dean-ing and scouring agent corrosion inhibitor in protective coatings pigment dispersant in nonaq. media o/w emulsifier Properties Lt. amber oily liq. sol. 25% in ethanol, IPA, acetone, MEK water-disp. sp.gr. 1.02 flash pt. > 93 C (PMCC) pH 6.5 cationic 99% solids... [Pg.318]

In contrast, there are no solvents used in HME processes for manufacturing amorphous solid dispersions. Instead, the mixture of crystalline drug and polymer are heated to a temperature at which the components melt or form a eutectic, and then flash cooled, resulting in a dense amorphous glassy solid. The solid is then milled to achieve uniform particle size distribution, which is then processed into the final formulation. Therefore, the milling step will determine particle size and surface area, which in turn is related to the dissolution rate of the solid. [Pg.499]

Uses Dispersant, antistat, emulsifier used in corrosion inhibitor formulations for oil field brines and HCI acidizing systems textile antistat Properties Gardner 6 max, liq, m.w, 339 flash pt. 58 F (PM) 49-52% quat. Adogen 477 [Evonik Goldschmidt GmbH]... [Pg.42]

Uses Emulsifier, lubricant, corrosion inhibitor for metalworking fluids, dispersant for textile formulations detergent in cleaner formulations Regulatory DOT, lATA, IMO not regulated SARA 311/312 Immediate Health Hazard Canada DSL Korea ECL Australia AlCS Philippines PICCS Properties Amber paste Gardner color 14 max. mild amine odor sp.gr. 0.99 flash pt. (COC) > 148 C pH (5% aq.) 9.0-10.5 volatiles < 1% neutralization equiv. 595-625 HLB 11.2 Use Level 0.25-1.0%... [Pg.250]

Uses Surfactant emulsifier in marine coatings biomass dispersant in oil field applications fragrance solubilizer, grease cutter in deodorizer formulations Properties Colorless to It. yel, liq, APHA 150 max. sp.gr, 0,89-0.97 vise. < 500 cps flash pt. 60 C pH 9-11 50% act,... [Pg.705]

Uses Emulsifier, dispersant, wetting agent for Ilq. formulations Including agrochemical formulations base for detergents In alkaline sol n Features Product darkens with age stable In alkaline, neutralized sol ns Properties Hazen 200 max. cl. Ilq. sol. In water and most polar and aromatic soivs. dens, 1,15 pour pt. 0 C flash pt > 100 C acid 1 67-72 100%... [Pg.930]

Chem. Descrip. Distearyl dimonium chloride Ionic Nature Cationic CAS 107-64-2 EINECS/ELINCS 203-508-2 Uses Textile softener wax replacement in sizing formulations Features Produces very slick cationic hand, max. sottness good nonyellowing, absorbency disperses at lower temp, than TA-100 Properties Powd. flash pt. (PMCC) > 200 F 100% solids Adol 52NF [Witco ]... [Pg.1260]

Uses Detergent and emulsifier for formulation of emulsion degreasers, esp. for removing grease and carbon from engine blocks, metals, and for mop treatments, hand cleaners, etc. water dispersant in fuel tank additives Properties Yel, vise, Iiq, complete sol. in kerosene, min. oils, aromatic soivs., chlorinated solve, pine oil sp.gr. 8.5 Ib/gal flash pt. 200 F pH 3.6 95% act. [Pg.1350]

Chem. Descrip. Polyalkyl methacrylate copolymer in hydrocarbon oil Uses Vise, index improver for formulation of hydraulic oils emulsifier, dispersant for emulsion polymerization reactive diluent for adhesives and coatings Properties Yel. vise, fluid sp.gr. 0.94 vise. 800 mm /s (100 C) pour pt 15 C flash pt. >100C... [Pg.1493]

Uses Antistat and wetting agent for personal care prods., textiles, plastics, lubricants and formulations solv.-based coating dispersant antitbam Fhopertes Liq. sp.gr. 1.03 vise. 2000 cSt cloud pt. 38 C (1% aq.) flash pt. (PMCC) > 300 F pour pt. -40 C surf. tens. 26.5 dynes/cm (1% aq.) 100% cone. [Pg.1662]

Uses Skin softener, nonoily emollient for cosmetic creams/lotions, bath oils, blushers, skin fresheners, aftershaves, nail enamel removers binder lubricant dispersant emulsifier food-pkg. adhesives, coatings, paper, polymers defoamer for aq. systems, food contact, mold release applies., paints, ceramics, grinding fluids, hydraulic fluids lubricant base for textiles, paper, metalworking formulations chemical intermediate for fatty acid esters component for urethanes Regulatory FDA 21CFR 173.310,173.340(a)(3), 175.105,175.300,175.380, 175.390,176.170(a)(5), 176.180,176.200,176.210,177.1680,178.3740 Properties APHA40 max. liq., polyol odor sol. 5% in min. oils, min. spirits, aromatic soivs., perchloroethylene insol. in water m.w. 2000 sp.gr. 1.002 vise. 150-175 cst (100 F) vapor pressure < 0.1 mm Hg b.p. > 300 F acid no. 1 max. pour pt. -31 C flash pt. (PMCC) > 350 F ref index 1.450 100% act. [Pg.1746]

Properties Yel. oily liquid m.w. 1311.70 dens. 1.044 flash pt. > 110 C hydroxyl value 165-195 sapon. value 95-115 acid value 3.0 Toxicology Moderately toxic by intravenous route TSCA listed Uses Emulsifier, solubilizer, lubricant for flavors, vitamins, textiles, household formulations, suppositories (phannaceuticals), emulsion polymerization, hydraulic fluids, metal treatment, paints color dispersant for plastics, cosmetics, leather emulsifier in cosmetics lubricant for fibers antistat stabilizer vise, modifier suspending agent in resinous/polymeric food-contact coatings Regulatory FDA 21CFR 175.300... [Pg.2375]

SOCCI 30 is a stable formulation of copper 8-quinolinolate dispersed in cordage oil. It is readily dilutable with oil formulations to meet the requirements of the manufacturer. A thixotropic paste which is miscible with toluol, xylol and high flash naphtha, SOCCI 30 can be incorporated into formulations consisting of cordage oil, wax and stearates. [Pg.188]

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