Formaldehyde respiratory system

Inhaled gaseous compounds are absorbed in all parts of the respiratory system whereas particle size determines how deep into the airways the parti cles will he transported in the airstrearn. Shortness of breath is a typical sign of a chemical exposure that has affected the lungs, and it may be evoked through iminunological mechanisms (e.g., formaldehyde, ethyleneoxide), or through toxic irritation (formaldehyde, isocyanates, sulfur dioxide, nitrogen dioxide, Frequently the mechanism depends on the concentration ol the com... 

Formaldehyde (also a VOC) ETS building materials and fabrics cleaning fluids and adhesives. irritation to eye. nose and respiratory system allergy, carcinogenic. 

Formic acid can be readily absorbed from the digestive tract and the respiratory system. Systemic absorption produces acidosis, neuropathy, and visual and mental disturbances. Acidosis can also be produced when formic acid is produced by liver aldehyde dehydrogenase from formaldehyde. Formaldehyde in turn can also be produced metabolically by alcohol dehydrogenase from methanol. Formic acid is oxidized to carbon dioxide by the folate-dependent pathway. Some formic acid is excreted unchanged in the urine. 

Most of the chemicals in Table 11.2 target the respiratory system and CNS. Exposures in arts and crafts use are almost always to mixtures of lipophilic and hydrophilic chemicals. When used in areas with poor air circulation (as is often the case in home use) the result can be unexpected acute toxicity. For example, it has been reported that exposure to formaldehyde and terpene hydrocarbons at very low levels unexpectedly produced dyspnea and other lower-lung symptoms in wood workers. The effects could not be attributed to either the formaldehyde or the terpenes alone at low levels of exposure In another example, it was reported that chronic exposure to a combination of very low concentrations of MEK, ethyl acetate, and aliphatic hydrocarbons in a leather adhesive formulation induced unanticipated CNS effects. Some products that are considered by most... 

Formaldehyde is a major contributor to many cases of sick building syndrome. It is a very toxic chemical that is corrosive to the skin, eyes, and the respiratory system. Acute or chronic exposure can result in difficulty breathing and even brief exposures can induce asthmatic reactions in sensitized individuals. 13 Exposures to mixtures of formaldehyde and lipophilic chemicals can result in unanticipated toxic effects. 14 Formaldehyde is an animal carcinogen, a suspected human nasal cancer carcinogen 29 and suspected human leukemogen. 3°1... 

Individually and collectively, assuming additive effects, one would not expect to observe the respiratory system, CNS, skin, and other symptoms reported by the employees in the subject building. The authors of the study concluded that although an outbreak of symptoms occurred, the causative agent(s) could not be identified. The Kqw values, however, show that three hydrophiles (formaldehyde, valeraldehyde, and 2-hexanone) and seven lipophiles (1,1,1-trichloroethane, styrene, ethyl benzene, toluene, TCE,... 

Tani T, Kogi K, Horiguchi Y. 1986. Inhibitory effects of formaldehyde inhalation on the cardiovascular and respiratory systems in unanesthetized rabbits. Jpn J Pharmacol 40 551-559. 

Formaldehyde can present a moderate to severe health hazard injuring eyes, skin, and respiratory system. It is a mutagen, teratogen, and probably carcinogenic to humans. It is a severe eye irritant. An amount of... 

Synonyms Methyiated-butyiated meiamine-formaidehyde resin Poly (melamine-co-formaldehyde), methylated/butylated Classification Formaldehyde copolymer Properties Dens. 1.096 flash pt. 110 C ref. index 1.5010 (20 C) Toxicology LD50 (oral, rat) > 5000 mg/kg, (skin, rabbit) > 5000 mg/kg toxic harmful by ing. inh., skin absorption irritating to eyes, skin, respiratory system sensitizer may cause allergic skin reaction cancer suspect agent mutagen... 

Respiratory history As noted above, formaldehyde has recognized properties as an airway irritant and has been reported by some authors as a cause of occupational asthma. In addition, formaldehyde has been associated with cancer of the entire respiratory system of humans. For these reasons, it is appropriate to include a comprehensive review of the respiratory system in the medical history. Components of this history might include questions regarding dyspnea on exertion, shortness of breath, chronic airway complaints, hyperreactive airway disease, rhinitis, bronchitis, bronchiolitis, asthma, emphysema, respiratory allergic reaction, or other preexisting pulmonary disease. 

Zhai L, Zhao J, Xu B, Deng Y, Xu Z. Influence of indoor formaldehyde pollution on respiratory system health in the urban area of Shenyang,... 

The toxicity of formaldehyde is related to its metabolic products and, as a result, individual variability in metabolism will determine toxic outcomes. Human ingestion of 118 ml of formaldehyde was fatal in some cases but not others. Systemic acidosis may appear upon ingestion along with corrosion and hemorrhaging of the digestive tract. Allergic sensitization may occur after exposure. This may lead to contact dermatitis after subsequent skin exposure, as well as asthmatic attack upon inhalation exposure. Inhalation may also result in irritation of the respiratory tract and pulmonary edema. 

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