Respiratory system sensitizer

HEALTH SYMPTOMS inhalation (coughing, shortness of breath, build-up of fluid in lungs, wheezing, chest tightness, irritates eyes, skin and respiratory system) skin absorption (respiratory system sensitization, skin sensitization, narcotic effects) contact (destroys tissues of mucous membranes, chemical bums to the skin and eyes, scarring, skin allergies). 

ACUTE HEALTH RISKS irritation of eyes, skin and mucous membranes can cause severe skin bums may severely bum the eyes irritation to nose, throat, and lungs coughing shortness of breath pulmonary edema respiratory system sensitization narcosis coma. 

Synonyms Methyiated-butyiated meiamine-formaidehyde resin Poly (melamine-co-formaldehyde), methylated/butylated Classification Formaldehyde copolymer Properties Dens. 1.096 flash pt. 110 C ref. index 1.5010 (20 C) Toxicology LD50 (oral, rat) > 5000 mg/kg, (skin, rabbit) > 5000 mg/kg toxic harmful by ing. inh., skin absorption irritating to eyes, skin, respiratory system sensitizer may cause allergic skin reaction cancer suspect agent mutagen... 

Toxia ogy Imtating to eyes, skin, respiratory system sensitizer possible mutagen TSCA listed Storage Light-sensitive Uses Photoinitiator for coatings, inks MattuT/DisHb. Aldrich... 

Properties M.w. 240.30 dens. 1.003 b.p. 87 C (0.6 mm) ref. index 1.4530 Toxicology Irritating to eyes, skin, respiratory system sensitizer TSCA listed Uses Comonomer for crosslinked acrylic/vinyl resins... 

Toxicology Toxic harmful if ing., inh. or absorbed thru skin irritating to eyes, skin, respiratory system sensitizer may cause allergic skin reaction cancer suspect agent mutagen TSCA listed... 

RESPIRATORY SENSITIZER (asthmagen) A substance which can cause an individual s respiratory system to develop a condition which makes it over-react if the substance is inhaled again. Such an individual is sensitized over-reaction is then likely to occur at concentrations of the substance which have no effect on unsensitized persons and lead to characteristic symptoms, e.g. rhinitis (a runny nose), conjunctivitis or in severe cases asthma or alveolitis. 

Health Hazards Information - Recommended Personal Protective Equipment Amine-type canister goggles or face shield rubber gloves Symptoms Following Exposure Vapors from hot liquid can irritate eyes and upper respiratory system. Liquid burns eyes and skin. May cause sensitization of skin General Treatment for Exposure INHALATION remove victim to fresh air INGESTION do NOT... 

Irritating to respiratory system 43 May cause sensitization by skin... 

Causes irritation to skin, eyes, and respiratory system, CNS stimulation, skin irritation, sensitization. Causes severe eye and skin burns. May cause severe tearing, conjunctivitis, and corneal edema. Inhalation may cause difficulties ranging from coughing and nausea to accumulation of fluid in the lungs (pulmonary edema). 

Colorless, water-white, or pale-yellow, oily liquid with a mild, skunk-like odor detectable at 0.5 ppm. This material is hazardous through inhalation and ingestion, and produces local skin/eye impacts. It causes irritation to the eyes, skin, respiratory system cough dizziness, dyspnea (breathing difficulty), lassitude (weakness, exhaustion), confusion, cyanosis abdominal pain, nausea skin sensitization. 

Thus the total soil pollution was connected with a respiratory system and a digestive tract. Both systems were also sensitive to such urban pollutants as heavy metals and PAH. For radionuclides the correlation with the given nosologies was not revealed. The asthma morbidity was mostly connected with soil pollution rates. This circumstance, apparently, can be related to nonspecific action of pollutants on a human organism, because the etiology of asthma is connected with the human immune defense system and allergy state (Roite, 1991). The last was shown for pesticides (Nikolaev et al., 1988) and heavy metals (Drouet et al., 1990). The sensitized immune system is, apparently, responsible for chronic toxic effects of other pollutants at low doses (Sidorenko et al., 1991 Novak and Magnussen, 1993). 

People who suffer from other pulmonary diseases that interrupt the flow of oxygen are especially sensitive to the irritating effects of SO2 and its particulate derivatives. This gas and several other gaseous air pollutants, to be mentioned in a moment, can cause other, delayed toxic effects in the respiratory system. Note also that these same chemicals are the principal causes of acid rain. 

Symptoms of exposure Severe skin irritant producing sensitization and blistering of the skin. Liquid splashed in eyes may cause injury (Patnaik, 1992). Inhalation may cause irritation of nose and respiratory system (NIOSH, 1997). 

Several chronic inhalation and oral studies and acute dermal studies in animals are reported in the literature. These studies exposed several species of animals to both soluble and less-soluble nickel compounds. The target organs were found to be the respiratory system for inhalation exposure and the respiratory system, gastrointestinal tract, hematological system, and kidneys for oral exposure at high levels. Reproductive and developmental effects were observed in animals after inhalation exposure and after oral exposure to nickel. Nickel sensitivity and dermatitis were also observed. 

More qualitative indicators are also useful absorption through healthy skin, irritation to skin, eyes, and respiratory system, together with sensitization with the following indicators carcinogenic, mutagenic, teratogenic, reprotoxic, and so on. These properties can be summarized by indication of a toxicity class. 

Similarly, no respiratory effects were found in rats and mice chronically exposed by diet to 5/ 10" and 1.3 10s g/kg/day of 2,7-DCDD, respectively (NCI/NTP 1979a). In contrast, rats exposed chronically by gavage to a mixture of 1,2,3,6,7,8-HxCDD and 1,2,3,7,8,9-HxCDD at 0.18, 0.34, and 0.7 g/kg/day had a dose-related increased incidence of adenomatous hyperplastic lesions in terminal bronchioles and adjacent alveoli of both males and females no such effects were found in mice exposed chronically to 0.7 g/kg/day of that same mixture (NCI/NTP 1980). The existing information suggests that in animals, the respiratory system is not a sensitive target for CDDs toxicity via oral exposure. 

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