Factors influencing biological

In situations where the partition coefficient is the only factor influencing biological activity, the parabolic curve can be expressed by the mathematical equation ... 

In many ways, analysis of the factors influencing biological electron transfer is analogous to the study of electric conduction in macroscopic systems. The properties of conducting systems may be described by Ohm s law ... 

One of the major factors influencing biological availability and toxic action of particle-bound metal compounds is their solubility under the pH and ionic strength conditions of human body fluids. Mullins and Norman (1994) measured metals in windblown dust from mine wastes as a function of particle size, which determines where in the respiratory tract the particle-bound metals will eventually settle, and as a function of solubility in different body fluids. They found that compounds of Cd and Mn in the < 10-pm fraction were highly soluble in simulated stomach fluid (40 to 91%) and simulated lung fluid (27 to 100%). Compounds of As were fairly soluble in stomach fluid (17 to 37%) but not in lung fluid (0.1 to... 

The variation in soil degradation rates depend on factors influencing biological activity including temperature, moisture, and oxygen tension along with those factors that control the availability of the substrate. 

Many different factors influence the performance of biological treatment systems. Although each specific biological process has special requirements, factors common to biological processes, besides biodegradabihty, include organic concentration, temperature, pH, nutrients, and oxygen (aerobic or anaerobic). 

The 2 -chloro and 2 -bromo congeners of either 748 (FIAC) or 758 (FMAU) are more cytotoxic than FIAC and FMAU, suggesting that these chloro and bromo nucleosides, in contrast to the 2 -fluoro compounds, are comparatively better substrates for deoxycytidine kinase of human lymphocytes than the substrates for viral-specific thymidine kinase. The disposition of the 2 -fluoro group may also be important from the biological viewpoint. It should be noted that the structural difference between RNA and DNA is at the 2 -position. The ribo type of analog (738) of FIAC is 10 times less effective in suppression of HSV replication than is FIAC. Thus Fox, and Watanabe and coworkers concluded that the 2 - up fluorine disposition and the species of the substituent at C-5 are the two important factors influencing antiviral activity. Nevertheless, the mechanism of action of 2 -deoxy-2 -fluorocytidine (737) on certain herpes viruses, including HSV-1... 

A. Biological Factors Influencing Oral Sustained-Release Dosage Form Design... 

Such longitudinal studies could show how social class factors influence health throughout the life cycle, and motivate investigations into the biological pathways linking class and health, e.g. the National Population Health Survey in Canada, begun in 1994. 

Davis, R.H., E.A. Elzubeir, and J.S. Craston. 1988. Nutritional and biochemical factors influencing the biological effects of cyanide. Pages 219-231 in D. Evered and S. Harnett (eds.). Cyanide Compounds in Biology. Ciba Foundation Symposium 140. John Wiley, Chichester. 

Throughout the text we will relate polymer structure to the properties of the polymer. Polymer properties are related not only to the chemical nature of the polymer, but also to such factors as extent and distribution of crystallinity, distribution of polymer chain lengths, and nature and amount of additives, such as fillers, reinforcing agents, and plasticizers, to mention a few. These factors influence essentially all the polymeric properties to some extent including hardness, flammability, weatherability, chemical stability, biological response, comfort, flex life, moisture retention, appearance, dyeability, softening point, and electrical properties. 

Randrup A, Munkvad 1, Fog R, et al Mania, depression and brain dopamine, in Current Developments in Psychopharmacology, Vol 2. Edited by Essmann WB, ValzeUi L. New York, Spectrum Publications, 1975, pp 206-248 Rapee RM Psychological factors influencing the affective response to biological challenge procedures in panic disorder. J Anxiety Disord 9 59-74, 1995 Rapee RM, Medoro L Pear of physical sensations and trait anxiety as mediators of the response to hyperventilation in nonclinical subjects. J Abnorm Psychol 103 693-699, 1994... 

DiPaolo, J.A., Donovan, P.J. and Nelson, R.L. (1971b). "In vitro transformation of hamster cells by polyCyclic hydrocarbons factors influencing the number of cells transformed, Nature New Biology 230,240. 

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