Eye products

Do not use nonprescription eye products during or after treatment unless such use has been approved by the primary healdi care provider. 

This preservative is comparatively new to ophthalmic preparations and is a polymeric quaternary ammonium germicide. Its advantage over other quaternary ammonium seems to be its inability to penetrate ocular tissues, especially the cornea. It has been used at concentrations of 0.001-0.01% in contact lens solutions as well as dry eye products. At clinically effective levels of preservative, POLYQUAD is approximately 10 times less toxic than benzalkonium chloride [87,137], Various in vitro tests and in vivo evaluations substantiate the safety of this compound [137,141,142], This preservative has been extremely useful for soft contact lens solutions because it has the least propensity to adsorb onto or absorb into these lenses, and it has a practically nonexistent potential for sensitization. Its ad-sorption/absorption with high water and high ionic lenses can be resolved by carefully balancing formulation components [143],... 

Dexamethasone and betamethasone are corticosteroids available for topical application in eye products. Docusate sodium is indicated for ear wax removal. 

Fortunately, many therapeutic agents used in eye products are water-soluble compounds or can be formulated as water-soluble salts, and a sufficiently high solution concentration can be achieved in the administered dose. In comparison with more sophisticated multiphase... 

Traditionally, ophthalmic liquid products were packed in glass containers fitted with rubber teats for the eye dropper. Glass containers have (limited) use today when there are product stability or compatibility issues which exclude the use of flexible plastic containers made of polyethylene or polypropylene. Most liquid eye products on the market are plastic containers fitted with nozzles from which, by gentle squeezing, the contents may be expressed as drops. 

Due to the safety and regulatory concerns raised by preservatives used in ophthalmic products, there have been efforts to develop new eye-drop packaging systems which can remove the preservative from the formulation during administration. BKC is the most common preservative used in commercial eye-drops, and yet there are reports of side-effects such as allergic reactions, irritation, decreased lacrimation and damage to the corneal endothelium caused by its multiple use in eye products (Fraunfelder and Meyer 1989). Also, BKC can... 

It should be noted that any eye product containing BKC preservative is contraindicated in patients wearing soft contact lenses. Wherever possible, wearers of such lenses should remove them before administration and allow time for the medication to be removed by the tears. Otherwise, the use of a unit-dose preparation is another option. 

Finally, compatibility tests can be carried out to demonstrate that the drug product is compatible with other commercially available eye products which may be co-administered. Each mixture is examined for signs of chemical and physical compatibility over a short period of time. These in vitro results should be validated by the successful use of the drug product with concomitant therapy in clinical studies. 

Note also that although EP, USP and WHO extractive procedures (see also BS 5736 parts 1-10) give only limited information and are usually mandatory only for eye products and injectables, this type of test may be useful for company assessment of various types of plastics. Compatibility tests at the feasibility stage may involve so-called accelerated or stress conditions. It should be recorded that higher temperatures may in some way either destroy the pack or make it less effective,... 

Products for making-up the face and the eyes Products for removing make-up from the face and eyes... 

Use Concentration 1,5% in hair grooming products 1.5% in suntan products 1.5% in eye products... 

Uses Emollient, solubilizer, foam modifier for syn. detergents and personal care products conditioner in shampoos, shampoo-condtioners, and rinse conditioners also used as a spreadability agent makeups, lipsticks and eye products solvent/ emollient in make-up and mascara removers. 

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