Ethanol interaction

The disulfiram-ethanol interaction is described above. Depending on the dose of disulfiram, sensitivity to disulfiram, amount of alcohol consumed, and metabolism, patients may be at risk to have an adverse interaction with alcohol for 2 to 14 days after stopping disulfiram (5 days on average) and... 

Alcoholism is a chronic relapsing disorder 922 Ethanol interacts directly with ligand-gated and voltage-gated ion channels 922... 

Brien JF et al A study of the calcium carbimide-ethanol interaction in man. Eur J Clin Pharmacol 14 133-1, 1978... 

Brodie MS et al Ethanol interactions with calcium-dependent potassium channels. Alcohol Clin Exp Res 2007 31 1625. [PMID 17850640]... 

In contrast to retinoids, carotenoids were considered non-toxic, even when taken chronically in large amounts, until recently, when it was found that ethanol interacts with carotenoids, interfering with their conversion to retinol. In baboons, the consumption of ethanol together with beta-carotene resulted in more striking hepatic injury than consumption of either compound alone (98). This interaction occurred at a total dose of 7.2-10.8 mg of beta-carotene per Joule of diet. This dose is common in people who take supplements and is the same order of magnitude used in the Beta-Carotene and Retinol Efficacy Trial (CARET) (30 mg/day) (99) and in another study (20 mg/day for 12 weeks) (100). The amount of alcohol given to the baboons was equivalent to that taken by an average alcohohc. The well-known toxicity... 

All workers agree that the products are formed by an initial dehydration step and Derouane et al used n.m.r. and g.l.c. to study the products obtained from methanol and ethanol interaction with ZSM-5 zeolite in the range 250-400 °C. At temperatures <300 C the products were the usual respective ether and olefin, but when temperatures > 300 °C were used Ca-Cs-olefins and aromatics were obtained, the overall reaction being expressed as (Scheme 12) ... 

Djordjevic D, Nikolic J, Stefanovic V. Ethanol interactions with other cytochrome P450 substrates including drugs, xenobiotics and carcinogens. Pathol Biol 1998 46(10) 760-70. 

MacDonald AJ, Rostami Hodjegan A, Tucker GT, Linkens DA. Analysis of solvent central nervous system toxicity and ethanol interactions using a human population physiologically based kinetic and dynamic model. Regul Toxicol Pharmacol 2002 35(2 Pt 1) 165 76. 

The system ethanol-ionic liquid is characterised by different potential interactions (Fig. 7) the anion can act as a hydrogen bond acceptor, either resulting in interactions with the OH-group of ethanol (interaction 1) or with the cation, especially if an imidazolium-based ionic liquid possesses an acidic proton at its C-2 position (interaction 2) [29, 93-103],... 

Furthermore, the electron pairs of oxygen in ethanol can act as acceptors, leading to possible hydrogen bonds between ethanol and acidic cationic positions (interaction 3) and intermolecular interactions of ethanol (interaction 4). However, in the case of series of homologues of a cation at constant ethanol concentrations, the effects of these interactions are likely similar and were thus disregarded for the interpretation. 

Many brain functions depend on a balance between excitatory and inhibitory neurotransmission. It is likely that the diverse effects of ethanol result from alterations in this balance. Although ethanol interacts with several receptor and channel systems, the detailed mechanisms are not yet understood. 

Flushed red skin may be caused by carbon monoxide poisoning, boric acid intoxication, chemical burns from corrosives or hydrocarbons, or anticholinergic agents. It may also result from vasodilation (eg, phenothiazines or disulfiram-ethanol interaction). 

Levamlsole G+, M+, N+ May have nicotinic and muscarinic effects at cholinergic receptors. Gastroenteritis, dizziness, headache after 2.5-mg/kg dose repotted. Fatality reported after ingestion of 15 mg/kg in a 3-year-old and 32 mg/kg in an adult. Disulfiram-like ethanol interaction may also occur. 

Procarbazine hydrochloride An+, D+, En+, G++, M++, N++ Monoamine oxidase inhibitor activity. Disulfiram-like ethanol interaction. 

B. Disuifiram-ethanol interaction. Ingestion of as little as 7 mL of ethanol can cause a severe reaction in patients taking as little as 200 mg/day of disulfiram. Mild reactions have been reported after use of cough symp, after-shave lotions, and other alcohol-containing products. 

Disulfiram-ethanol interaction. Decontamination procedures are not likely to be of benefit once the reaction begins. 

D. Enhanced elimination. Hemodialysis is not indicated for disulfiram overdose, but it may remove ethanol and acetaldehyde and has been reported to be effective in treating the acute disulfiram-ethanol interaction. This is not iikeiy to be necessary in patients receiving adequate fluid and pressor support. There are no data to support the use of repeat-dose activated charcoal for any of the disulfiram syndromes. 

Mendelsm J, Jones RT, Upton R, Jacob P. Meth phetamine and ethanol interactions in humans. Clin Pharmacol Iher ( 995) 57, 559-68. 

Cina SJ, Russell RA, Conradi SE. Sudden death due to metronidazole/ethanol interaction. Am J Forensic Med Pathol (1996) 17, 343-6. 

Messiha FS. Cerebral and peripheral neurotoxicity of chloipromazine and ethanol interaction implications for alcohol and aldehyde dehydrc enase-AfeMrotoCTCo/o (1991) 12,559-70. 

Curry SH, Smith CM. Diazepam-ethanol interaction in humans addition or potentiation Commm Psychopharmacol (1979) 3,101-13. 

Dorian P, Sellers EM, Kaplan HL, Hamilton C, Greenblatt DJ, Abemethy D. Triazolam and ethanol interaction kinetic and dynamic consequences. Clin Pharmacol Ther (1985) 37,... 

Brien JF, Peachey JE, Loomis CW. Calcium carbimide-ethanol interaction. Clin Pharmacol... 

Bird KD, Boleyn T, Chesher GB, Jackson DM, Starmer GA, Teo RKC. Intercannabinoid and cannabinoid-ethanol interactions and their effects on human performance. Psychopharmacology (Bed) (19 0) 71, 181-8. 

Riihimaki V, Laine A, Savolainen K, Siiifiel H. Acute solvent-ethanol interactions with cial reference to xylene. ScandJ Work Environ Healdi (1982) 8, 77-9. 

Drug-drag interactions Ethanol A 50-year-old man developed intractable hypotension, which led to ischemic electrocardiographic changes and myocardial damage as a result of a disulfiram-ethanol interaction [30 ]. 

The twin topics of the identification of isoquinoline alkaloids during alcohol intoxication, and the pharmacology of isoquinoline alkaloids and ethanol interactions, have recently been reviewed. 

This is attributed to the steric exclusion effect when the charge dipole length is very short, which prevents the -OH head from attaching to the surface charges. In this case, weak van der Waals interactions dominate the surface-ethanol interactions because the surface-ethanol electrostatic interactions can be neglected. 

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