For enhanced elimination

Dichlorobenzene distributes to fatty tissues and is probably retained there at low concentrations (EPA 1986d Hawkins et al. 1980 Morita and Ohi 1975 Morita et al. 1975). However, most of an absorbed dose is excreted within 5 days of exposure (Hawkins et al. 1980), and there is no evidence suggesting that the low levels of 1,4-dichlorobenzene that are likely to remain in fatty tissues would cause adverse effects. For these reasons, methods for enhancing elimination of 1,4-dichlorobenzene shortly after high-dose exposure could reduce toxic effects however, no such methods have been identified. Methods that could enhance the elimination of 1,4-dichlorobenzene after high- or low-dose exposure in humans or laboratory animals have not been reported. 

After appropriate diagnostic and decontamination procedures and administration of antidotes, it is important to consider whether measures for enhancing elimination, such as hemodialysis or urinary alkalinization, can improve the clinical outcome. Table 58-3 lists intoxications for which dialysis may be beneficial. 

D. Enhanced elimination. There is no role for enhanced elimination the toxin binds rapidly to nerve endings, and any free toxin can be readily detoxified with antitoxin. 

D. Enhanced elimination. There is no role for enhanced elimination. 

D. Enhanced elimination. Because of the very large volumes of distribution of the opioids and the availability of an effective antidotal treatment, there is no role for enhanced elimination procedures. 

One possible method for enhancing elimination is increasing the ventilation rate. In a single case report, controlled hyperventilation over a 5-day period enhanced pulmonary elimination in a 6-year-old boy who had ingested between 12 and 16 grams of tetrachloroethylene (Koppel et al. 1985). 

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