Dynamic consequences

But assume that those barriers are overcome and a pharmaceutical company markets an important drug based on pharmacogenomics. Assume, for example, that pharmacogenomics research allows the firm to know which 80% of the population will benefit from the drug, which 10% will receive absolutely no benefit, and which 10% will be seriously harmed by it. The short-term consequence would be to improve health outcomes of everyone, not just the 80% who would benefit but the other 20% who should not take the drug. The dynamic consequences are less clear. If such pharmacogenomic... 

Further extensions of the model are required to address the dynamical consequences of these additional regulatory loops and of the indirect nature of the negative feedback on gene expression. Such extended models have been proposed for Drosophila [112, 113] and mammals [113]. The model for the circadian clock mechanism in mammals is schematized in Fig. 3C. The presence of additional mRNA and protein species, as well as of multiple complexes formed between the various clock proteins, complicates the model, which is now governed by a system of 16 or 19 kinetic equations. Sustained or damped oscillations can occur in this model for parameter values corresponding to continuous darkness. As observed in the experiments on the mammalian clock. Email mRNA oscillates in opposite phase with respect to Per and Cry mRNAs [97]. The model displays the property of entrainment by the ED cycle... 

Greenblatt, D.J., Wright, C.E., von Moltke, L.L., Harmatz, J.S., Eh-renberg, B.L., Harrel, L.M., Corbett, K., Counihan, M., Tobias, S., and Shader, R.I. (1998) Ketoconazole inhibition of triazoloam and alprazolam clearance differential kinetic and dynamic consequences. Clin Pharmacol Ther 64 237-247. 

The aim of this study is to describe the dynamical consequences (e.g. thermal response) of the middle atmosphere, which are directly related to the ozone distribution by using a mechanistic three-dimensional model of the middle atmosphere and the 3-D GEOS ozone data. 

Dameris M., U.Berger, G.Guenter and A.Ebel, (1991) The ozone hole dynamical consequences as simulated with a three-dimensional model of the middle atmosphere Ann. Geophysicae 9, p. 661 -668,... 

Greenblatt DJ, Wright CE, von Moltke LL, et al. Ketoconazole inhibition of triazolam and alprazolam clearance differential kinetic and dynamic consequences. Clin Pharmacol Ther 1998 64 237-247. 

Throughout the previous studies of IVR/VP processes, the cluster vibrational phase space has been separated into two distinct regions—the high frequency chromophore modes and the low frequency van der Waals modes. When this is the case, virtually the entire contribution to the total density of vibrational states comes from the van der Waals modes. Thus, in the absence of VP, IVR results in the almost complete and irreversible flow of energy from the chromophore to the van der Waals modes. 4-Ethylaniline(4EA)/Ar, N2, CH4 clusters are studied to explore the dynamical consequences of low frequency chromophore modes (Hineman et al. 1993a). 

Equations (1.14) and (1.15) contain divergent terms that are independent of the particles positions. These terms occur whenever r - r( and represent the electrostatic interaction of each particle with itself. However, because these terms are independent of the particles positions, subtracting them from the electrostatic energy is equivalent to a simple redefinition of the zero-point energy of the particles. Since all forces in nature derive from changes in energy, such a redefinition of the zero point of energy is of no dynamical consequence. 

Lim EC (1986) Proximity effect in molecular photophysics Dynamical consequences of pseudo-Jahn-Teller interaction. Journal of Physical Chemistry 90 6770-6777. 

In summary, because of a dynamical consequence of symmetry in this model, the vibrationally excited asymmetric isotopomers, such as QOO, have approximately equal lifetimes that are longer than that of the symmetric isotopomers, such as 000 and OQO, Q being or At low pressures they have thereby an improved chance of being deactivated by a collision and so of forming a stable... 

The motion of the molecular system under the influence of the potential is determined by the equations of dynamics. Consequently the shape of the computed PES governs entirely this motion. As explained in the previous section, since... 

A delicate point in such mixed quantum-classical schemes is the self-consistency between the classical and quantum motions. The time-dependent variation of the electronic Hamiltonian arising from the nuclear dynamics results in electronic transitions. These quantum transitions, on the other hand, influence the forces on the nuclei, often with dramatic dynamical consequences. 

A third important advantage of the SCF methods is that they provide a unified framework within which one can treat both energy-level calculations and dynamical processes. Having a unified language and closely related descriptions of spectroscopy and of energy transfer dynamics is attractive because both reflect on properties of the potential energy surface, and should best be used in conjunction to study the surface and its energetic and dynamical consequences. 

But what are possible dynamic consequences of such an equivariance breaking perturbation to a lattice group As many authors before us, we describe such consequences in terms of the tip motion of meandering spirals. We would like to keep in mind, however, that the prominently visible phenomenon of the tip motion only amounts to a visualization of the translational component of the SE 2) coordinates, which we will derive in section... 

Each field free potential curve, V (R), generates a family of field-dressed potentials, Vj>n(iJ), with the result that many intersections between potential curves occur that are not present in the field-free case. The spectroscopic and dynamical consequences of these field-dressed curve crossings are understood using exactly the same methods presented in this book for field-free intersecting potentials. 

We employ a classical description of the dynamical consequences of such a quantum object as the hydrogen bond. This concerns, for instance, the vibration of HB molecules. The price we pay for such an approach is that several fitted model parameters (e.g., force constants) are not related explicitly to the molecular structure of our object. Note that in the MD simulation method, based on application of various effective potentials, the classical theory is also often used [33-35]. Avery detailed analysis of the problems pertinent to the two-fractional (mixed) models of water is given in the latter work (review) with respect to various (mostly steady-state) properties of water. In the context of our work, the use of a classical mixed model is justified by a possibility of considering a simplified picture of two-state molecular motion allowing a relatively simple analytical calculation of the complex permittivity s(v) given in Section II. 

Dynamic consequences of dielectric losses It is dear that for a substance with dielectric loss, for example water and the alcohols, the molecules do not perfectly follow the oscillations of the electric field. For media without dielectric loss, and for the same reasons as under static conditions, the strength of the electric field cannot induce rotation for all polar molecules, but statistically only for a small part (less than 1%). This means that all the molecules osdllate round an average direction (precession motion), as shown in Fig. 1.9. 

Dorian P, Sellers EM, Kaplan HL, Hamilton C, Greenblatt DJ, Abemethy D. Triazolam and ethanol interaction kinetic and dynamic consequences. Clin Pharmacol Ther (1985) 37,... 

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