Eosinophilic pneumonia

Eosinophilic pneumonia Pulmonary infiltrates with eosinophilia. If this occurs during the course of therapy, discontinue the drug. 

Eosinophilic infiltrations have been described with tolbutamide (SEDA-8, 917 90), and chronic eosinophilic pneumonia has been described with chlorpropamide (91) and tolazamide (92). 

Bondi E, Slater S. Tolazamide-induced chronic eosinophilic pneumonia. Chest 1981 80(5) 652. 

Tanigawa K, Sugiyama K, Matsuyama H, Nakao H, Kohno K, Komuro Y, Iwanaga Y, Eguchi K, Kitaichi M, Takagi H. Mesalazine-induced eosinophilic pneumonia. Respiration 1999 66(l) 69-72. 

Jaffuel D, Lebel B, HiUaire-Buys D, Pene J, Godard P, Michel FB, Blayac IP, Bousquet J, Demolyi P. Eosinophilic pneumonia induced by dapsone. BMJ 1998 317(7152) 181. 

There has also been a report of an acute eosinophilic pneumonia associated with peripheral blood eosinophilia in a patient with follicular lymphoma (5). 

Trojan A, Meier R, Licht A, Tavema C. Eosinophilic pneumonia after administration of fludarabine for the treatment of non-Hodgkin s lymphoma. Arm Hematol 2002 81(9) 535-7. 

In one patient, interstitial pulmonary edema with pulmonary failure was supposedly a first-dose reaction (24). Reversible eosinophilic pneumonia has also been reported (SEDA-19, 342). 

A 33-year-old man with a 3-year history of Crohn s disease had previously received a weU-tolerated single infusion of infliximab. When, 14 months later, he received a second infusion for exacerbation of the disease he had no immediate adverse effects, but complained of myalgia, arthralgia, nausea, and vomiting 7 days later and received diphenhydramine. After 3 days he had dyspnea, fever, and chills. An open lung biopsy showed features of eosinophilic pneumonia and no... 

Data on the safety of loxoprofen are based on an open, multicenter trial of about 4000 elderly patients in Japan (SEDA-17, 112). Adverse effects were mainly gastrointestinal, but other adverse effects, common to every NSAID, included edema, dizziness, skin rashes, pruritus, and a case of eosinophilic pneumonia and liver dysfunction (SEDA-17,112). 

Immunoallergic reactions have been reported with minocycline and include lupus-like syndrome, autoimmune hepatitis, eosinophilic pneumonia, hypersensitivity syndrome, a serum sickness-like illness (29), and Sweet s syndrome (SEDA-21, 262) (SEDA-22, 271). Over 60 minocycline-induced cases of lupus-like syndrome and 24 cases of minocycline-induced autoimmune hepatitis were found in a review of the literature (30). In 13 patients, both disorders co-existed. These patients had symmetrical polyarthralgia/polyarthritis, raised liver enzymes, and positive antinuclear antibodies they were also generally antihistone-negative, and only two patients had p-ANCA antibodies. Minocycline-related lupus can also occur in adolescents (31). 

Atypical courses have been rarely described (5). A mixed type of reaction can occur after an initial short fever peak, the patient becomes either afebrile or subfeb-rile, despite continuing to take nitrofurantoin and unabated activity of the lung process, or a typical chronic reaction converts to a typical acute reaction on re-expo-sure to nitrofurantoin after withdrawal. Acute reactions can occur without clinical symptoms, and can be recognized only on X-ray. Single cases of pulmonary hemorrhage, eosinophilic pneumonia, and interstitial giant cell pneumonia have also been reported (26,27). 

Acute eosinophilic pneumonia after one dose of inhaled pentamidine of 300 mg has been reported the reaction subsided within 2 weeks but recurred on rechallenge (SEDA-18, 292). 

Acnte eosinophilic pneumonia has been attributed to pranoprofen in a 48-year-old man (2). 

Eosinophilic pneumonia of acute onset has been attributed to roxithromycin (5). 

Perez-Castrillon JL, Jimenez-Garcia R, Martin-Escudero JC, Velasco C. Roxithromycin-induced eosinophilic pneumonia. Ann Pharmacother 2002 36(ll) 1808-9. 

Berliner S, Neeman A, Shoenfeld Y, Eldar M, Rousso I, Kadish U, Pinkhas J. Salazopyrin-induced eosinophilic pneumonia. Respiration 1980 39(2) 119-20. 

Acute eosinophilic pneumonia has been described in a man with osteoarthritis taking tenidap sodium (2). 

AUen JN, Liao Z, Wewers MD, et al. Detection of IL-5 and IL-1 receptor antagonist in bronchoalveolar lavage fluid in acute eosinophilic pneumonia. J Allergy Clin Immunol 1996 97 1366-74. 

Kelly KJ, Ruffing R. 1993. Acute eosinophilic pneumonia following intentional inhalation of Scotchguard. Ann Allergy 71 358-361. 

Some cases of eosinophilic pneumonia have been described after sulfonamides (Feinmann 1975 Thomas et al. 1974 Anonymous 1974). Furthermore, pathological liver changes are reported similar to those in hepatitis, sometimes with a cholestatic component which recurred after repeated application of sulfonamides (Iwarson and Lundin 1979 Steinbrecher and Mischkin 1981). 

Donlan CJ, Scutero JV (1975) Transient eosinophilic pneumonia secondary to use of a vaginal cream. Chest 67 232... 

Constantinides KA (1976) Eosinophilic pneumonia. An unusual side effect ot therapy with salicylazosulfapyridine. Chest 70 315-316... 

Sertraline, but not risperidone, has been previously reported to cause eosinophilic pneumonia. 

Respiratory A 51-year-old man developed an eosinophilic pneumonia with pulmonary alveolar hemorrhage while taking benzbromarone 50 mg/day [58 ]. 

Sakamoto N, Ishii H, Ishimatsu Y, Kohno S. Drug-induced eosinophilic pneumonia with pulmonary alveolar hemorrhage caused by benz-bromarone. Intern Med 2010,49(5) 435-8. 

Lai Y, Assimacopoulos AP. Two cases of daptomycin-induced eosinophilic pneumonia and chronic pneumonitis. Clin Infect Dis 2010 50(5) 737-40. 

McGrane J, Paravasthu M, Candlish W, Gravil J. Unilateral balsalazide-induced eosinophilic pneumonia in an ulcerative colitis patient. J R Coll Physicians Edinb 2010 40 216-8. 

J arisch-Herxheimer reaction, 390 Nicolau s s5mdrome, 390 ben romarone eosinophilic pneumonia, 189 benznidazole anorexia, 489 dermatological reactions,... 

Respiratory Bronchiolitis-Associated Interstitial Lung Disease 341 Desquamative Interstitial Pneumonia 341 Lymphoid Interstitial Pneumonia 342 Acute Interstitial Pneumonia 342 Sarcoidosis 343 Miscellaneous Rare Forms of Interstitial Lung Disease of Unknown Etiology 345 Pulmonary Langerhans Cell Histiocytosis 345 Lymphangioleiomyomatosis 345 Eosinophilic Pneumonia 346 Pulmonary Alveolar Proteinosis 348 Pulmonary Microlithiasis 348... 

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