Herxheimer reaction

Jarisch-Herxheimer reaction following treatment of syphilis, brucellosis, schistosomiasis, or trypanosomiasis... [Pg.87]

Additionally, some patients may experience fever, chills, tachycardia, and tachypnea, a condition commonly known as the Jarisch-Herxheimer reaction. Postulated to occur secondary to spirochete lysis and proinflammatory cytokine cascades, this reaction may transpire as early as 2 hours after penicillin administration and usually resolves within 24 hours. Treatment is supportive and may include antipyretic and antiinflammatory agents, as well as fluid resuscitation and bed rest. [Pg.1163]

Adverse reactions CNS Convulsions, confusion, drowsiness, myoclonus, fever Dermatologic Rash Metabolic Electrolyte imbalance Hematologic Positive Coombs test, hemolytic anemia Local Rain, thrombophlebitis Renal Acute interstitial nephritis Miscellaneous Anaphylaxis, hypersensitivity, Jarisch-Herxheimer reaction CNS Seizures, confusion, drowsiness, myoclonus, CNS stimulation Cardiovascular Myocardial depression, vasodilation, conduction disturbances Hematologic Positive Coombs test, hemolytic anemia, neutropenia Local Thrombophlebitis, sterile abscess at injection site Renal Interstitial nephritis Miscellaneous Pseudoanaphylactic reactions, hypersensitivity, Jarisch-Herxheimer reaction, serum sickness... [Pg.1165]

The majority of patients treated for primary and secondary syphilis experience the Jarisch-Herxheimer reaction after treatment, characterized by flu-like symptoms such as transient headache, fever, chills, malaise, arthralgia, myalgia, tachypnea, peripheral vasodilation, and aggravation of syphilitic lesions. [Pg.513]

The Jarisch-Herxheimer reaction should not be confused with penicillin allergy. Most reactions can be managed symptomatically with analgesics, antipyretics, and rest. [Pg.513]

Leptospirosis. To be maximally effective, chemotherapy should be started within 4 days of the onset of symptoms. Benzylpenicillin is recommended a Herxheimer reaction may be induced (see Syphilis). General supportive management is important, including attention to fluid balance and observation for signs of hepatic, renal or cardiac failure. [Pg.254]

Friedland JS, Warrell DA. The Jarisch-Herxheimer reaction in leptospirosis possible pathogenesis and review. Rev Infect Dis I99I I3(2) 207-I0. [Pg.494]

Maloy AL, Black RD, Segurola RJ Jr. Lyme disease complicated by the Jarisch-Herxheimer reaction. J Emerg Med 1998 16(3) 437-8. [Pg.494]

Young EJ, Weingarten NM, Baughn RE, Duncan WC. Studies on the pathogenesis of the Jarisch-Herxheimer reaction development of an animal model and evidence against a role for classical endotoxin. J Infect Dis I982 I46(5) 606-15. [Pg.494]

Negussie Y, Remick DG, DeForge LE, Kunkel SL, Eynon A, Griffin GE. Detection of plasma tumor necrosis factor, interleukins 6, and 8 during the Jarisch-Herxheimer reaction of relapsing fever. J Exp Med 1992 175(5) 1207-12. [Pg.494]

Fekade D, Knox K, Hussein K, Melka A, Lalloo DG, Coxon RE, Warrell DA. Prevention of Jarisch-Herxheimer reactions by treatment with antibodies against tumor uecrosis factor alpha. N Eugl J Med 1996 335(5) 311-15. [Pg.494]

A Jarisch-Herxheimer reaction to ciprofloxacin has been reported (61). [Pg.785]

Webster G, Schiffman ID, Dosanjh AS, Amieva MR, Gans HA, Sectish TC. Jarisch-Herxheimer reaction associated with ciprofloxacin administration for tick-borne relapsing fever. Pediatr Infect Dis J 2002 21(6) 571-3. [Pg.788]

There have been reports of a Herxheimer reaction and of skin lesions resembling toxic epidermal necrolysis, both in children (SEDA-13, 825). [Pg.2776]

The Jarisch-Herxheimer reaction is common in patients treated with tetracyclines for louse-borne relapsing fever (43). Two forms of reaction are described at the start of tetracycline therapy (a) fever, rigor, increased respiratory and heart rates, and occasional delirium and coma (44) (b) fever and disseminated intravascular coagulation (45). At about the time the temperature reaches its peak, spirochetes disappear from the peripheral blood (44). Meptazinol, a partial opioid antagonist, reduces the Jarisch-Herxheimer reaction in relapsing fever (46). [Pg.3332]

Bleeding with thrombocytopenia and signs of intravascular coagulation in patients treated for louse-borne relapsing fever may be due to a Jarisch-Herxheimer reaction mediated by the release of endotoxins from disintegrating spirochetes (43). [Pg.3332]

Zein ZA. Louse borne relapsing fever (LBRF) mortality and frequency of Jarisch-Herxheimer reaction. J R Soc Health 1987 107(4) 146-7. [Pg.3339]

Teklu B, Habte-Michael A, Warrell DA, White NJ, Wright DJ. Meptazinol diminishes the Jarisch-Herxheimer reaction of relapsing fever. Lancet 1983 l(8329) 835-9. [Pg.3339]

Wolf B +, Acta Derm Venereol (Stockh) 72, 441 Jarisch-Herxheimer reaction (2003) Leblebicioglu H +, EurJ din Microbiol Infect Dis 22(10), 639... [Pg.33]

Jarisch-Herxheimer reaction (1994) Strominger MB +, J Neuroophtbalmol 14, 77 Linear IgA dermatosis (1999) Yawalker N +, Dermatology 199, 25 Pemphigus... [Pg.107]

Saeed SA+, Postgrad Med J 76(899), 577 (lymphomatoid) (I 998) Romano A+, J Allergy Clin Immunol 101,564 Jarisch-Herxheimer reaction... [Pg.108]

Pandhi RK+, Australasian J Dermatol 26, 88 Gray syndrome Hypersensitivity Jarisch-Herxheimer reaction (1983) Perine PL+, Am J Trop Med Hyg 32(5), 1096... [Pg.115]

Moreno-Ancillo A+, Contact Dermatitis 49(1), 44 Jarisch-Herxheimer reaction Pruritus... [Pg.141]

Jarisch-Herxheimer reaction (I 993) Amita DB +, Clin Exp Dermatol 18, 389 Lichenoid eruption... [Pg.271]

Gonzalez-Delgado P +, Ann Allergy 73, 326 (1992) Verschueren GL +, Contact Dermatitis 26, 47 Jarisch-Herxheimer reaction Photosensitivity... [Pg.322]

Fields DA, West] Med 133, 521 Exfoliative dermatitis Hematoma Hypersensitivity Jarisch-Herxheimer reaction Pruritus Psoriasis Purpura Rash (1-10%)... [Pg.367]

Keller K+, Contact Dermatitis 27, 348 Jarisch-Herxheimer reaction Jaundice... [Pg.380]

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