Benz bromarone

Uricosurics, such as probenecid or benz-bromarone (100 mg/day), promote renal excretion of uric acid. They saturate the organic acid transport system in the proximal renal tubules, making it unavailable for urate reabsorption. When underdosed, they inhibit only the acid secretory system, which has a smaller transport capacity. Urate elimination is then inhibited and a gout attack is possible. In patients with urate stones in the urinary tract, uricosurics are contraindicated. 

Sakamoto N, Ishii H, Ishimatsu Y, Kohno S. Drug-induced eosinophilic pneumonia with pulmonary alveolar hemorrhage caused by benz-bromarone. Intern Med 2010,49(5) 435-8. 

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