Drugs acting

Some of the most effective cholesterol lowering drugs act by inhibiting the enzyme that catalyzes this reaction... 

Another quinazoline, prazosin (1040), is now a widely used antihypertensive drug, acting by vasodilation (77MI21300, B-81MI21301) its preparation is outlined in the patent literature (72NEP7206067). 

There is evidence the drug acts as an antimetabolite for the i ira-aminobenzoic acid required for bacterial metabolism.) One oT the more recent of the many preparations for this drug involves carboxylation of meta-aminophenol (6) by means of ammonium i.ii bonate under high pressure. ... 

All drug parameters are predicated on an accurate knowledge of the concentration of drug acting at the receptor. Errors in this independent variable negate all measures of dependent variables in the system. 

The pharmacological and/or adverse effects of a drug can be reversed by co-administration of drugs which compete for the same receptor. For example, an opioid receptor antagonist naloxone is used to reverse the effects of opiates. Drugs acting at the same site with opposite effects also can affect each other, e.g. the reduction in the anticoagulant effect of warfarin by vitamin K. 

The Orphan Drug Act of 1983 was passed to encourage die development and marketing of products used to treat rare diseases. The act defines a rare disease as a condition affecting fewer than 200,000 individuals in die United States. The National Organization of Rare Disorders reports that there are more tiian 6000 rare disorders that affect approximately 25 million individuals. Examples of rare disorders include Tourette s syndrome, ovarian cancer, acquired immunodeficiency syndrome (AIDS), Huntington s disease, and certain forms of leukemia... 

Many laws have been enacted over the last century that affect drug distribution and administration. Those included here are the Pure Food and Drug Act Harrison Narcotic Act Pure Food, Drug, and Cosmetic Act and the Comprehensive Drug Abuse Prevention and Control Act. These laws control the use of the three categories of drugs in the United States (prescription, nonprescription, and controlled substances). 

The macrolides are bacteriostatic or bactericidal in susceptible bacteria The drugs act by binding to cell membranes and causing changes in protein function. 

SUMMARY DRUG TABLE DRUGS ACTING ON THE UTERUS... 

Brimonidine tartrate is an alph -adrenergic receptor agonist used to lower IOP in patients with open-angle glaucoma or ocular hypertension. This drug acts to reduce aqueous humor production and increase the outflow of aqueous humor. 

The original Food and Drugs Act is passed prohibiting misbranded and adulterated food and drugs. 

Orphan Drug Act passed, enabling FDA to promote research and marketing of drugs needed for treating rare diseases. 

The Pure Food and Drug Act established the Food and Drug Administration (FDA). 

The Delaney Amendment to the Food and Drug Act addressed the control of food additives. 

S. R Gupta, QSAR studies on drugs acting at the central nervous system. Chem. Rev. 1989, 89, 1765-1800. 

Some drugs act as Indicators (e.g. phenolphthaleln, vegetable laxatives) and affect tests carried out at a particular pH. The presence of sulfobromophthaleln dye (BSP) In serum will Interfere with serum protein determined by the biuret method. 

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