Adrenergic system drugs acting

The atypical tricyclic antidepressant amineptine (Survector) is an indirect dopamine agonist, which selectively inhibits dopamine uptake and induces its release, with additional stimulation of the adrenergic system. Its antidepressant effects are similar to those of other tricyclic antidepressant drugs. However, it acts more rapidly, is better... 

In terms of the noradrenergic system, this chapter has described the locus co-eruleus as that part of the brain containing the noradrenergic neurons that mediate some of the symptoms of anxiety through alpha 2 and beta adrenergic receptors. Our discussion has also extended to the role of serotonin in anxiety, which appears to be key, yet quite complex and incompletely understood. One current theory developed in this chapter is the notion that anxiolytic drugs act as partial agonists at serotonin 1A receptors. 

Basic and advanced life-support measures should be utilized as necessary. Treatment is directed at ameliorating tachycardias, shock, cardiac arrhythmias, systemic hypertension, pulmonary edema, and lactic acidosis. In the case of severe toxicity, administration of a rapidly acting a-adrenergic blocking drug such as phentolamine may be considered. 

Metabolism of adrenaline and noradrenaline 200 Commonly used drugs acting on the adrenergic system 201... 

COMMONLY USED DRUGS ACTING ON THE ADRENERGIC SYSTEM... 

The adrenergic system is one of the most physiologically complex. The drags discussed in this chapter will be described roughly in order of their frequency of usage. Thus we start with drugs acting at Pi and P2 receptors. 

Commonly Used Drugs Acting on the Adrenergic System... 

Sympathetic arc involved in blood pressure regulation and sites where drugs may act to influence the system. A. Receptors on effector cell. 6. Adrenergic varicosity. C. Nicotinic receptors (postganglionic fibers). D. Brainstem nuclei. NTS, nucleus of the tractus solitarii VMC, vasomotor center ACh, acetylcholine NE, norepinephrine a, a-adrenoceptors (3, 13-adrenoceptors P2, P2-purinoceptors ATR adenosine triphosphate. 

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