Drug Importation Act

The Drug Importation Act passed to stop the entry of adulterated drugs. 

Awareness of the Committee of Revision in 1851 of the importance of keeping the Pharmacopeia up-to-date may have been enhanced because of the enactment of the Drug Import Act in 1848, which mandated that drugs imported into the United States had to meet the standards of the county of origin and had to comply with the... 

Unites States Congress passes Drug Importation Act that allows United States Customs Service inspection to stop entry of foreign drugs. 

In 1848, however, the first U.S. drug law, the Drug Importation Act, was enacted when American troops serving in Mexico became seriously ill from the quinine that was administered to treat malaria. The quinine was subsequently discovered to be adulterated. This law required laboratory inspection, detention, and even... 

Aspirin is an important antiplatelet drug that acts by inhibiting production of thromboxane A2. 

Over the last ten years or so, the emphasis on selectivity of action has waned. This is because the relative importance of blocking noradrenaline and 5-HT reuptake remains uncertain and it is possible that it could be beneficial to block both. Some drugs that act in this way have already been developed. It is hoped that this approach might increase the response rate of patients who are resistant to more selective drug treatments and even reduce the therapeutic lag that dogs their predecessors. As yet, there is not enough information on these compounds to know whether or not this has turned out to be the case. 

Partitioning into the CNS will be important for hallucinogens, as for any drug that acts centrally. Correlation between 1-octanol/water partition coefficients and human activity has been reported (13). Regression analysis of log human activity on log P yielded a parabolic fit with an optimum at log P 3.14. The derived equation accounted for only 62% of the variance but included compounds with a variety of substitution patterns and, presumably, qualitative differences in activity. 

Peptidases encoded by many viruses play essential roles at various stages of viral replication, including the coordinated assembly and maturation of virons [7a]. Viral peptidases have become important drug targets in the treatment of viral infections. Of note are inhibitors of proteases of the human immunodeficiency virus (HIV), particularly HIV-1 protease (HIV-1 retropepsin, EC 3.4.23.16) and HIV-2 protease [47-50], Drugs in this class, which include indinavir, ritonavir, and saquinavir, are useful in the treatment of AIDS, especially when administered as a cocktail together with one of the drugs that act on the viral retrotranscriptase (e.g., didanosine, stavudine, and zidovudine (AZT)). 

Generic Drug Enforcement Act of 1992. The following sections summarise some of the more important enforcement provisions used by FDA to regulate all pharmaceutical products. 

For much of the second half of the twentieth century the benzodiazepines were the mainstay of the treatment of anxiety. Despite well-publicised concerns about their long-term safety, they remain an important therapeutic option. The anticonvulsants contain a number of drugs that act via GABA or glutamate neurotransmission and have a limited but interesting role in the treatment of particular anxiety disorders. 

Pathogenesis of systemic abnormalities during pancreatitis is associated with a high concentration of pancreatic proteases in the blood, which reduce activation of the blood proteolytic systems. Alteration of the balance between proteases and their natural inhibitors is a trigger of endogenous intoxication syndrome, which controls disease severity and the clinical outcome. Therefore, drugs which act as inhibitors of proteases are an important component of a complex treatment of acute pancreatitis. 

Congress responded to concerns about impurities in drugs by passing an act that requires the U.S. Customs Service to inspect and stop from entry any adulterated drugs imported from overseas. 

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