Centrally acting drugs

Centrally acting drugs include dextromethorphan and codeine. However the possibility that there may also be peripheral effects of these drugs has lead to the development of BW443C (see below). 

Domino, E.F. Fukuda, N. and Simonic, A. Comparative electro-encephalographic and gross behavioral effects of phencyclidine, related substances and various centrally acting drugs in Macaca mul atta. In Kamenka, J.M. Domino, E.F. and Geneste, P., eds. Phencvli di ne and Rel ated Arvl cvclohexvlami nes Present and Future Appl i cat.i ons. Ann Arbor, MI NPP Books, 1983a. pp. 369-395. 

Novel centrally acting drugs may need to be tested for abuse potential. Primate... 

Concomitant conditions Use with caution in the following patients exposed to extreme heat or phosphorus insecticides atropine or related drugs because of additive anticholinergic effects those in a state of alcohol withdrawal those with dermatoses or other allergic reactions to phenothiazine derivatives because of the possibility of cross-sensitivity those who have exhibited idiosyncrasy to other centrally acting drugs. 

Hollister, L.E. (1982). In F. HofFmeister 8c G. StiUe (Eds.), Psychotropic Agents Part III. Alcohol and psychotomimetics, psychotropic effects of central acting drugs. (321-344). Berlin Springer Verlag. 

Pfeiffer A, Veilleux S, Barden N Antidepressant and other centrally acting drugs regulate glucocorticoid receptor messenger RNA levels in rat brain. Psychoneuroendocrinology 16 505-515, 1991... 

According to a definition by Coper and Kanowski (1983. p. 409), nootropics are centrally acting drugs intended to improve higher integrative noetic brain functions such as memory and the ability to learn, perceive, think and... 

Curran, H.Y., Pooviboonsuk, P., Dalton, JA., Lader, M.FL Differentiating the effects of centrally acting drugs on arousal and memory an event-related potential study of scopolamine, lorazepam and diphenhydramine. Psvchopharmacologv 135. 27-36. 1998. 

Van Hoogdalem, E.J., A.G. De Boer, and D.D. Breimer. 1991. Pharmacokinetics of rectal drug administration, Part I. General considereations and clinical applications of centrally acting drugs. Clin Pharmacokinet 21 11. 

Paul, V., Subramaniam, E., 1997. Effect of single and repeated administration of endosulfan on behavior and its interaction with centrally acting drugs in experimental animals a mini review. Environ. Toxicol. Pharmocol. 3, 151-157. 

Alpha2-adrenergic receptor agonists (centrally acting drugs)... 

Mandema, J. and Danhof, M., Electroencephalogram effect measures and relationships between pharmacokinetics and pharmacodynamics of centrally acting drugs, Clinical Pharmacokinetics, Vol. 23, No. 3, 1992, pp. 191-215. 

Mirsky, A. F. (1970). An overview of neuroelectrophysiologic studies of central-acting drugs. In A. DiMascio and R. Shrader (Eds.), Clinical handbook of psychopharmacology. New York Science House. 

The potentiation of sedative effects from benzodiazepines when combined with centrally acting drugs with antihistamine properties (for example first-generation antihistamines, tricyclic antidepressants, and neuroleptic drugs) can pose problems (143). Antihistamines that do not have central actions do not interact with benzodiazepines as in the case of mizolastine and lorazepam (144), ebastine and diazepam (145), and terfenadine and diazepam (143). 

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